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Chronic granulomatous disease associated with common variable immunodeficiency - 2 clinical cases
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Orientador(es)
Resumo(s)
INTRODUCTION:
Chronic granulomatous disease associated with common variable immunodeficiency (GD-CVID), although well documented, is rare. Granulomatous lesions can affect several organs and are histologically indistinguishable from sarcoidosis.
CLINICAL CASES:
Case 1: A 39-year-old male patient with CVID, asymptomatic although with thrombocytopenia and mediastinal-hilar adenopathies. GD-CVID was diagnosed by bone marrow biopsy. Progressive clinical and radiological improvement was obtained with corticotherapy. Case 2: A 38-year-old male patient with CVID, suffered from asthenia, anorexia, myalgia, lower limbs edemas, and dry cough. He had mediastinal and bilateral hilar adenopathies within which biopsy revealed non-necrotizing granulomatous infiltrate. A spontaneous resolution was detected after 9 months of evolution.
CONCLUSION:
GD-CVID is rare and can mimetize other pathologies, namely, sarcoidosis; it should therefore be publicized and discussed so that it becomes a general clinical knowledge.
Descrição
Palavras-chave
Doença Granulomatosa Crónica Imunodeficiência de Variável Comum
Contexto Educativo
Citação
Rev Port Pneumol. 2014 Jan 22. pii: S0873-2159(13)00159-1.