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Líquen plano oral : um estudo de corte prospetivo numa população portuguesa
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Advisor(s)
Abstract(s)
O LPO é uma doença crónica comum, que se caracteriza pelo seu aparecimento na cavidade oral e/ou nas mucosas e na pele e por ser autoimune. Objetivo: Este trabalho pretende analisar a prevalência desta patologia na população portuguesa e caracterizar o nosso grupo de doentes afetados por LPO de acordo com a idade, género, localização e tipos de lesões na cavidade oral, presença ou ausência de sintomas, tratamentos efetuados, etc… Materiais e Métodos: Foi efetuado um estudo de corte prospetivo com os doentes diagnosticados com LPO através dos registos clínicos dos doentes de uma Consulta de Medicina Oral na zona de Lisboa (Clínica Integrada de Medicina Oral – Doutores Pedro Trancoso e António Mano Azul). O estudo foi avaliado e aprovado pela Direção Clínica da Instituição. O estudo foi feito em total concordância com a Declaração de Helsínquia da Associação Médica Mundial (World Medical Association). Os dados referentes à informação clínica dos doentes e respetivo diagnostico histopatológico foram obtidos dos registos clínicos e transferidos para uma base de dados Microsoft Excel. Os dados foram anonimizados antes da análise. Nesta, foram incluídas informações sobre género, idade, local da lesão, diagnóstico clínico e histopatológico, grau de displasia, quando existente, tratamento, taxa de transformação maligna.
Resultados: O género mais afetado foi o feminino (72%). O grupo etário mais afetado foi dos 60 aos 69 anos. O tipo de LPO mais frequente foi o reticular e a localização anatómica da lesão de LPO mais comum foi a mucosa jugal. A maioria dos doentes desta amostra mostrou-se assintomática. Os corticosteroides foram a escolha de tratamento mais frequente.
Conclusão: O estudo presente mostra que as características da população portuguesa com LPO estudada são semelhantes aos grupos de outros estudos internacionais da bibliografia. Sendo possivelmente a doença mais prevalente da mucosa oral, é importante que os médicos dentistas tenham presente as suas caraterísticas clínicas já descritas (quer das formas brancas assintomáticas quer das formas vermelhas), o seu diagnóstico e como usar os imunossupressores no seu tratamento.
Oral lichen planus is a common chronic disease, characterized by its occurrence in the oral cavity and/or on mucous membranes and skin, and it is autoimmune in nature. Objectives: This work aims to analyze the prevalence of this pathology in the Portuguese population and to characterize our group of patients affected by OLP according to age, gender, location and types of lesions in the oral cavity, presence or absence of symptoms, treatments performed, etc. Materials and Methods: A prospective cohort study was conducted with patients diagnosed with OLP through the clinical records of patients from an Oral Medicine Clinic in the Lisbon area (Clínica Integrada de Medicina Oral – Doctors Pedro Trancoso and António Mano Azul). The study was reviewed and approved by the Clinical Direction of the Institution. The study was conducted in full compliance with the World Medical Association's Declaration of Helsinki. Data regarding the clinical information of the patients and their histopathological diagnoses were obtained from clinical records and transferred to a Microsoft Excel database. The data were anonymized before analysis. The analysis included information on gender, age, lesion location, clinical and histopathological diagnoses, degree of dysplasia, when present, treatment, and rate of malignant transformation. Results: The most affected gender was female (72%). The most affected age group was between 60 and 69 years old. The most common type of OLP was reticular, and the most common anatomical location of the OLP lesion was the buccal mucosa. The majority of patients in this sample were asymptomatic. Corticosteroids were the most frequently chosen treatment. Conclusion: The present study shows that the characteristics of the Portuguese population with OLP studied are similar to those of groups in other international studies in the literature. As it is possibly the most prevalent disease of the oral mucosa, it is important for dentists to be aware of its already described clinical characteristics (both asymptomatic white forms and red forms), its diagnosis, and how to use immunosuppressants in its treatment.
Oral lichen planus is a common chronic disease, characterized by its occurrence in the oral cavity and/or on mucous membranes and skin, and it is autoimmune in nature. Objectives: This work aims to analyze the prevalence of this pathology in the Portuguese population and to characterize our group of patients affected by OLP according to age, gender, location and types of lesions in the oral cavity, presence or absence of symptoms, treatments performed, etc. Materials and Methods: A prospective cohort study was conducted with patients diagnosed with OLP through the clinical records of patients from an Oral Medicine Clinic in the Lisbon area (Clínica Integrada de Medicina Oral – Doctors Pedro Trancoso and António Mano Azul). The study was reviewed and approved by the Clinical Direction of the Institution. The study was conducted in full compliance with the World Medical Association's Declaration of Helsinki. Data regarding the clinical information of the patients and their histopathological diagnoses were obtained from clinical records and transferred to a Microsoft Excel database. The data were anonymized before analysis. The analysis included information on gender, age, lesion location, clinical and histopathological diagnoses, degree of dysplasia, when present, treatment, and rate of malignant transformation. Results: The most affected gender was female (72%). The most affected age group was between 60 and 69 years old. The most common type of OLP was reticular, and the most common anatomical location of the OLP lesion was the buccal mucosa. The majority of patients in this sample were asymptomatic. Corticosteroids were the most frequently chosen treatment. Conclusion: The present study shows that the characteristics of the Portuguese population with OLP studied are similar to those of groups in other international studies in the literature. As it is possibly the most prevalent disease of the oral mucosa, it is important for dentists to be aware of its already described clinical characteristics (both asymptomatic white forms and red forms), its diagnosis, and how to use immunosuppressants in its treatment.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Líquen plano oral Prevalência Mucosa oral Patologia oral