Publication
Challenges in matrix metalloproteinases inhibition
| dc.contributor.author | Laronha, Helena | |
| dc.contributor.author | Carpinteiro, Inês | |
| dc.contributor.author | Portugal, Jaime | |
| dc.contributor.author | Azul, Ana | |
| dc.contributor.author | Polido, Mário | |
| dc.contributor.author | Petrova, Krasimira T. | |
| dc.contributor.author | Salema-Oom, Madalena | |
| dc.contributor.author | Caldeira, Jorge | |
| dc.date.accessioned | 2020-10-22T11:27:11Z | |
| dc.date.available | 2020-10-22T11:27:11Z | |
| dc.date.issued | 2020-05 | |
| dc.description | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | pt_PT |
| dc.description.abstract | Matrix metalloproteinases are enzymes that degrade the extracellular matrix. They have different substrates but similar structural organization. Matrix metalloproteinases are involved in many physiological and pathological processes and there is a need to develop inhibitors for these enzymes in order to modulate the degradation of the extracellular matrix (ECM). There exist two classes of inhibitors: endogenous and synthetics. The development of synthetic inhibitors remains a great challenge due to the low selectivity and specificity, side effects in clinical trials, and instability. An extensive review of currently reported synthetic inhibitors and description of their properties is presented. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Laronha, H.; Carpinteiro, I.; Portugal, J.; Azul, A.; Polido, M.; Petrova, K.T.; Salema-Oom, M.; Caldeira, J. Challenges in Matrix Metalloproteinases Inhibition. Biomolecules 2020, 10, 717. | pt_PT |
| dc.identifier.doi | doi.org/10.3390/biom10050717 | pt_PT |
| dc.identifier.issn | 2218-273X | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/33754 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | MDPI | pt_PT |
| dc.relation.publisherversion | https://doi.org/10.3390/biom10050717 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Matrix metalloproteinases | pt_PT |
| dc.subject | TIMP | pt_PT |
| dc.subject | Synthetic inhibitors | pt_PT |
| dc.title | Challenges in matrix metalloproteinases inhibition | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.startPage | 717 | pt_PT |
| oaire.citation.title | Biomolecules | pt_PT |
| oaire.citation.volume | 10(5) | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
Files
Original bundle
1 - 1 of 1