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Encephalitozoon cuniculi em coelhos (Oryctolagus cuniculi) de companhia: um estudo retrospetivo (2020 a 2022) na região Hauts-de-France, França
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Abstract(s)
Encephalitozoon cuniculi é um microsporídio com uma distribuição mundial. O seu hospedeiro principal
é o coelho doméstico (Oryctolagus cuniculi), podendo, contudo, infetar outras espécies, incluindo o
homem. No coelho, a infeção pode permanecer no estado subclínico ou causar encefalitozoonose.
Num quadro de doença, o animal pode apresentar, de forma isolada ou de forma conjunta, sinais
clínicos neurológicos, urinários ou oculares. Este trabalho teve como objetivo determinar a taxa de
seropositividade de E. cuniculi em coelhos de companhia na região Hauts-de-France nos anos 2020 a
2022, em França. Para tal, foi realizado um estudo retrospetivo em coelhos de estimação (n=238)
recebidos em consulta veterinária na “Clinique du Caducée”, e submetidos a um teste serológico de
deteção de anticorpos anti-Encephalitozoon cuniculi por imunofluorescência indireta. Os dados obtidos
permitiram observar uma taxa de seropositividade de 70% entre os animais testados. Por outro lado, a
análise estatística revelou associações significativas (p<0,05) entre a deteção de anticorpos anti-E.
cuniculi e a presença de head tilt, de nistagmo e, de uma forma geral, de síndrome vestibular. Por
último, verificou-se que a seropositividade tinha uma associação estatística significativa com a raça
anã, com os animais com idade igual ou superior a três anos, com os níveis elevados de ureia e de
creatinina, e também com a origem dos animais adquiridos em lojas de animais.
Encephalitozoon cuniculi is a microsporidia with worldwide distribution. Its main host is the domestic rabbit (Oryctolagus cuniculi) but it can infect other species, including humans. In rabbits, the infection may remain subclinical or cause encephalitozoonosis. In case of disease, the animal may present, separately or jointly, neurological, urinary or ocular clinical signs. The objective of this work was to determine the seropositive rate of E. cuniculi in pet rabbits in the Hauts-de-France region between 2020 and 2022, in France. For this, a retrospective study was conducted on pet rabbits (n=238) received in veterinary consultation at the "Clinique du Caducée" and subjected to a serological test for the detection of antibodies anti-Encephalitozoon cuniculi by indirect immunofluorescence. The data obtained showed a seropositive rate of 70% in the animals tested. On the other hand, statistical analysis revealed significant associations (p<0,05) between the detection of antibodies anti-E. cuniculi and the presence of head tilt, nystagmus and, in general, vestibular syndrome. Finally, seropositivity was found to have a significant statistical association with the dwarf breed, animals aged three years or older, high levels of urea and creatinine and animals purchased from pet shops.
Encephalitozoon cuniculi is a microsporidia with worldwide distribution. Its main host is the domestic rabbit (Oryctolagus cuniculi) but it can infect other species, including humans. In rabbits, the infection may remain subclinical or cause encephalitozoonosis. In case of disease, the animal may present, separately or jointly, neurological, urinary or ocular clinical signs. The objective of this work was to determine the seropositive rate of E. cuniculi in pet rabbits in the Hauts-de-France region between 2020 and 2022, in France. For this, a retrospective study was conducted on pet rabbits (n=238) received in veterinary consultation at the "Clinique du Caducée" and subjected to a serological test for the detection of antibodies anti-Encephalitozoon cuniculi by indirect immunofluorescence. The data obtained showed a seropositive rate of 70% in the animals tested. On the other hand, statistical analysis revealed significant associations (p<0,05) between the detection of antibodies anti-E. cuniculi and the presence of head tilt, nystagmus and, in general, vestibular syndrome. Finally, seropositivity was found to have a significant statistical association with the dwarf breed, animals aged three years or older, high levels of urea and creatinine and animals purchased from pet shops.
Description
Keywords
Encefalitozoonose França Imunofluorescência indireta Oryctolagus cuniculi Encephalitozoonosis France Indirect Immunofluorescence Oryctolagus cuniculi