Publication
Association between dietary intake and the expression of clock genes in adults: a brief report
| datacite.subject.fos | Ciências Médicas | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Lages, Marlene | |
| dc.contributor.author | Correia, Joana | |
| dc.contributor.author | Caseiro, Armando | |
| dc.contributor.author | Carmo-Silva, Sara | |
| dc.contributor.author | Barros, Renata | |
| dc.contributor.author | Ferreira-Marques, Marisa | |
| dc.contributor.author | Guarino, Maria P. | |
| dc.date.accessioned | 2025-12-04T13:47:13Z | |
| dc.date.available | 2025-12-04T13:47:13Z | |
| dc.date.issued | 2025-10-08 | |
| dc.description.abstract | Background: The circadian system regulates several physiological processes, including energy metabolism, through the expression of core clock genes. Animal studies suggest that dietary composition can influence circadian gene expression; however, evidence in humans remains limited. Objective: This study aimed to explore the association between dietary macronutrient intake and the expression of circadian clock genes in the whole blood of adults with distinct metabolic profiles. Methods: Nineteen adults (94.7% female; 43.4 ± 16.05 years) were categorized into healthy-weight and overweight/obesity groups based on BMI. Dietary intake was assessed using a 3-day food diary, and clock gene expression (CLOCK, BMAL1, PER2, CRY) was evaluated in whole blood samples collected between 08:00 a.m. and 04:00 p.m. Statistical analyses included group comparisons and correlation analyses between macronutrient intake and gene expression. Results: No statistically significant differences were observed in the clock gene expression between BMI groups, although group-level trends were noted, particularly in PER2 and CRY expression. The overweight/obesity group exhibited a significantly higher percentage of energy intake from protein. Correlation analyses revealed several time-dependent associations between macronutrient intake and clock gene expression. Notably, in the healthy BMI group, BMAL1 and CRY expression correlated with lipid and protein intake, while in the overweight/obesity group, CLOCK expression was strongly associated with both lipid and carbohydrate intake. Conclusion: These findings suggest that macronutrient composition may influence peripheral circadian gene expression in a time- and BMI-dependent manner. Further research is necessary to confirm these associations in larger and more diverse populations and to investigate the potential for chrononutrition strategies to support metabolic health | eng |
| dc.identifier.citation | Lages M, Barros R, Ferreira-Marques M, Correia J, Caseiro A, Guarino MP and Carmo-Silva S (2025) Association between dietary intake and the expression of clock genes in adults: a brief report. Front. Nutr. 12:1663559. doi: 10.3389/fnut.2025.1663559 | |
| dc.identifier.doi | 10.3389/fnut.2025.1663559 | |
| dc.identifier.eissn | 2296-861X | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/60229 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Frontiers Media | |
| dc.relation.hasversion | https://doi.org/10.3389/fnut.2025.1663559 | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.subject | chrononutrition | |
| dc.subject | circadian rhythms | |
| dc.subject | diet | |
| dc.subject | obesity | |
| dc.subject | clock genes | |
| dc.title | Association between dietary intake and the expression of clock genes in adults: a brief report | por |
| dc.type | text | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 11 | |
| oaire.citation.startPage | 1 | |
| oaire.citation.title | Frontiers in Nutrition | |
| oaire.citation.volume | 12 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |