Publicação
Association between IL-1A, IL-1B and IL-1RN polymorphisms and peri-implantitis : a systematic review and meta-analysis
| datacite.subject.fos | Ciências Médicas | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Cardoso, José Maria | |
| dc.contributor.author | Duarte, Sofia | |
| dc.contributor.author | Ribeiro, Ana Clara | |
| dc.contributor.author | Mascarenhas, Paulo | |
| dc.contributor.author | Noronha, Susana | |
| dc.contributor.author | Alves, Ricardo Castro | |
| dc.date.accessioned | 2025-11-03T15:53:25Z | |
| dc.date.available | 2025-11-03T15:53:25Z | |
| dc.date.issued | 2022-07 | |
| dc.description.abstract | Recent studies report that individuals with polymorphisms in the genes that encode for interleukin (IL)-1α and IL-1β (IL-1A and IL1B, respectively) and for IL-1 receptor antagonist (IL-1RN) may be more susceptible in developing peri-implantitis. Therefore, the current systematic review evaluates what is reported about the role of genetics, more specifically of single nucleotide polymorphisms (SNP) on IL-1 and variable number of tandem repeats (VNTR) on IL-1RN, in the development of peri-implantitis. This systematic review was carried out by screening PubMed, B-on, Cochrane and Scopus databases, for articles English, Spanish, and Portuguese, with no limit regarding the publication year. Eight articles were selected for systematic review and four for meta-analytic syntheses. Our results show that although there is a lack of consensus in the literature, there seems to be an association between IL-1A, IL-1B, and IL-1RN polymorphisms with peri-implantitis. The results of the meta-analysis showed that patients who have the polymorphic allele at position +3954 of the IL-1B gene have on average almost twice the risk of developing peri-implantitis (odds ratio = 1.986, 95% confidence interval). | eng |
| dc.identifier.citation | Cardoso JM, Duarte S, Ribeiro AC, Mascarenhas P, Noronha S, Alves RC. Association between IL-1A, IL-1B and IL-1RN Polymorphisms and Peri-Implantitis: A Systematic Review and Meta-Analysis. Applied Sciences. 2022; 12(14):6958. https://doi.org/10.3390/app12146958 | |
| dc.identifier.doi | 10.3390/app12146958 | |
| dc.identifier.issn | 2076-3417 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/59494 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation.hasversion | https://doi.org/10.3390/app12146958 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | genetics | |
| dc.subject | peri-implantitis | |
| dc.subject | interleukin-1 | |
| dc.subject | interleukin-1 receptor antagonist | |
| dc.subject | interleukin-1 genotype | |
| dc.subject | genetic polymorphisms | |
| dc.subject | peri-implant disease | |
| dc.title | Association between IL-1A, IL-1B and IL-1RN polymorphisms and peri-implantitis : a systematic review and meta-analysis | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 14 | |
| oaire.citation.startPage | 6958 | |
| oaire.citation.title | Applied Sciences | |
| oaire.citation.volume | 12 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |