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Polyvinyl alcohol/chitosan wound dressings loaded with antiseptics

2021-01Journal article Restricted access
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dc.contributor.authorMassarelli, E.
dc.contributor.authorSilva, D.
dc.contributor.authorPimenta, A. F. R.
dc.contributor.authorFernandes, A.I.
dc.contributor.authorMata, J. L. G.
dc.contributor.authorArmês, H.
dc.contributor.authorSalema-Oom, Madalena
dc.contributor.authorSaramago, B.
dc.contributor.authorSerro, A.P.
dc.date.accessioned2022-09-13T11:58:13Z
dc.date.available2022-09-13T11:58:13Z
dc.date.issued2021-01
dc.description.abstractWound care remains a challenge in healthcare. This work aimed to develop a new polyvinyl alcohol (PVA)/chitosan (Ch) based wound dressing able to ensure protection, hydration and a controlled release of antiseptics, as alternative to actual treatments. Two distinct formulations (1:1 and 3:1, w/w) were prepared, sterilized by autoclaving and characterized concerning surface morphology, degradation over the time, mechanical properties and hydrophilicity. Both dressings revealed adequate properties for the intended purpose. The dressings were loaded with chlorhexidine (CHX) and polyhexanide (PHMB) and the drug release profiles were determined using Franz diffusion cells. The release of PHMB was more sustained than CHX, lasting for 2 days. As the amounts of drugs released by PVA/Ch 1:1 were greater, the biological tests were done only with this formulation. The drug loaded dressings revealed antibacterial activity against S. aureus and S. epidermidis, but only the ones loaded with PHMB showed adequate properties in terms of cytotoxicity and irritability. The application of this elastic dressing in the treatment of wounds in a dog led to faster recovery than conventional treatment, suggesting that the material can be a promising alternative in wound care.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMassarelli E, Silva D, Pimenta AFR, Fernandes AI, Mata JLG, Armês H, Salema-Oom M, Saramago B, Serro AP. Polyvinyl alcohol/chitosan wound dressings loaded with antiseptics. Int J Pharm. 2021 Jan 25;593:120110. doi: 10.1016/j.ijpharm.2020.120110.pt_PT
dc.identifier.doi10.1016/j.ijpharm.2020.120110pt_PT
dc.identifier.issn0378-5173
dc.identifier.urihttp://hdl.handle.net/10400.26/41802
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationSterilization of clinically active hydrogels: looking for efficient strategies
dc.relation.publisherversionhttps://doi.org/10.1016/j.ijpharm.2020.120110pt_PT
dc.subjectChitosanpt_PT
dc.subjectChlorhexidinept_PT
dc.subjectControlled drug releasept_PT
dc.subjectPolyhexanidept_PT
dc.subjectPolyvinyl alcoholpt_PT
dc.subjectWound dressingpt_PT
dc.titlePolyvinyl alcohol/chitosan wound dressings loaded with antisepticspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSterilization of clinically active hydrogels: looking for efficient strategies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM-BIO%2F3640%2F2014/PT
oaire.citation.startPage120110pt_PT
oaire.citation.titleInternational Journal of Pharmaceuticspt_PT
oaire.citation.volume593(25)pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameHenriques Dias Fernandes
person.familyNameSeabra de Oliveira Salema Cordeiro Oom
person.familyNameValagão Amadeu do Serro
person.givenNameAna Isabel
person.givenNameMaria Madalena
person.givenNameAna Paula
person.identifierhttps://scholar.google.com/citations?hl=pt-PT&user=twKmG28AAAAJ&scilu=&scisig=AMD79ooAAAAAXlBc7TYHlBnQjG3Qkf1CtIy0CWZF-Y8C&gmla=AJsN-F76qFk-8ML2Ezmxdlnemk8SgkNKEVkhKYcq8eGMqXtfcbwJXua8h5h4mjcl8SLRNMH7UKoG_k4iikE2aqChj6Gsi-Zb1kfF4KjcfiOdAZpdiuTK2BhuMuPI8eh
person.identifierB-3331-2012
person.identifierH-7797-2012
person.identifier.ciencia-idA318-3221-BD19
person.identifier.ciencia-id1312-AA9F-B69F
person.identifier.ciencia-idC012-F8B6-A58E
person.identifier.orcid0000-0003-2705-4845
person.identifier.orcid0000-0002-5668-6705
person.identifier.orcid0000-0002-6179-9296
person.identifier.scopus-author-id7201782197
person.identifier.scopus-author-id8842624900
person.identifier.scopus-author-id6603259828
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctPolítica de copyright da editorapt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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