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New findings in HCV genotype distribution in selected West European, Russian and Israeli regions

2016-08Journal article Open access
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dc.contributor.authorKartashev, Vladimir
dc.contributor.authorDöring, Matthias
dc.contributor.authorNieto, Leonardo
dc.contributor.authorColetta, Eleda
dc.contributor.authorKaiser, Rolf
dc.contributor.authorSierra, Saleta
dc.contributor.authorHCV EuResist Study group
dc.contributor.authorGuerrero, A.
dc.contributor.authorStoiber, H.
dc.contributor.authorPaar, C.
dc.contributor.authorVandamme, A. M.
dc.contributor.authorNevens, F.
dc.contributor.authorRanst, M. Van
dc.contributor.authorCuypers, L.
dc.contributor.authorBraun, P.
dc.contributor.authorEhret, R.
dc.contributor.authorObermeier, M.
dc.contributor.authorSchneeweiss, S.
dc.contributor.authorScholten, S.
dc.contributor.authorRömer, K.
dc.contributor.authorIsernhagen, K.
dc.contributor.authorQurashi, N.
dc.contributor.authorHeger, E.
dc.contributor.authorKnops, E.
dc.contributor.authorNeumann-Fraune, M.
dc.contributor.authorTimm, J.
dc.contributor.authorWalker, A.
dc.contributor.authorLübke, N.
dc.contributor.authorWedemeyer, H.
dc.contributor.authorWiesch, J. Schulze zur
dc.contributor.authorLütgehetmann, M.
dc.contributor.authorPolywka, S.
dc.contributor.authorDäumer, M.
dc.contributor.authorHoffmann, D.
dc.contributor.authorProtzer, U.
dc.contributor.authorMarascio, N.
dc.contributor.authorFoca, A.
dc.contributor.authorLiberto, M. C.
dc.contributor.authorBarreca, G. S.
dc.contributor.authorGalati, L.
dc.contributor.authorTorti, C.
dc.contributor.authorPisani, V.
dc.contributor.authorPerno, C. F.
dc.contributor.authorCeccherini-Silberstein, F.
dc.contributor.authorCento, V.
dc.contributor.authorCiotti, M.
dc.contributor.authorZazzi, M.
dc.contributor.authorRossetti, A.
dc.contributor.authorDe Luca, A.
dc.contributor.authorCaudai, C.
dc.contributor.authorMor, O.
dc.contributor.authorDevaux, C.
dc.contributor.authorStaub, T.
dc.contributor.authorAraujo, F.
dc.contributor.authorGomes, P.
dc.contributor.authorCabanas, J.
dc.contributor.authorMarkin, N.
dc.contributor.authorKhomenko, I.
dc.contributor.authorGovorukhina, M.
dc.contributor.authorLugovskaya, G.
dc.contributor.authorDontsov, D.
dc.contributor.authorMas, A.
dc.contributor.authorMartró, E.
dc.contributor.authorSaludes, V.
dc.contributor.authorRodríguez-Frías, F.
dc.contributor.authorGarcía, F.
dc.contributor.authorCasas, P.
dc.contributor.authorIglesia, A. de la
dc.contributor.authorAlados, J. C.
dc.contributor.authorPena-López, M. J.
dc.contributor.authorRodríguez, M. J.
dc.contributor.authorGalán, J. C.
dc.contributor.authorSuárez, A.
dc.contributor.authorCardeñoso, L.
dc.contributor.authorGuerrero, M. D.
dc.contributor.authorVegas-Dominguez, C.
dc.contributor.authorBlas-Espada, J.
dc.contributor.authorGarcía, R.
dc.contributor.authorGarcía-Bujalance, S.
dc.contributor.authorBenítez-Gutiérrez, L.
dc.contributor.authorMendoza, C. de
dc.contributor.authorMontiel, N.
dc.contributor.authorSantos, J.
dc.contributor.authorViciana, I.
dc.contributor.authorDelgado, A.
dc.contributor.authorMartínez-Sanchez, P. A.
dc.contributor.authorFernández-Alonso, M.
dc.contributor.authorReina, G.
dc.contributor.authorTrigo, M.
dc.contributor.authorEcheverría, M. J.
dc.contributor.authorAguilera, A.
dc.contributor.authorNavarro, D.
dc.contributor.authorBernal, S.
dc.contributor.authorLozano, M. C.
dc.contributor.authorFernández-Cuenca, F.
dc.contributor.authorOrduña, A.
dc.contributor.authorEiros, J. M.
dc.contributor.authorOrtíz de Lejarazu, R.
dc.contributor.authorMartínez-Sapiña, A. M.
dc.contributor.authorGarcía-Díaz, A.
dc.contributor.authorHaque, T.
dc.date.accessioned2019-12-20T12:51:02Z
dc.date.available2019-12-20T12:51:02Z
dc.date.issued2016-08
dc.descriptionThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).pt_PT
dc.description.abstractBACKGROUND: HCV affects 185 million people worldwide and leads to death and morbidities. HCV has a high genetic diversity and is classified into seven genotypes and 67 subtypes. Novel anti-HCV drugs (Direct-Acting-Antivirals) eligibility, resistance and cure rates depend on HCV geno/subtype (GT). OBJECTIVES: Analysis of epidemiological information and viral GT from patients undergoing viral genotyping in 2011-2015. STUDY DESIGN: Anonymized information from 52 centers was analyzed retrospectively. RESULTS: 37,839 samples were included in the study. We show that the GT distribution is similar throughout Western European countries, with some local differences. Here GTs 1 and 2 prevalences are lower and of GT4 higher than in all previous reports. Israel has a unique GT pattern and in South Russia the GT proportions are more similar to Asia. GTs 5 and 6 were detected in very low proportions. Three cases of the recombinant genotype P were reported in Munich (Germany). In addition, we observed that GT proportion was dependant on patientś gender, age and transmission route: GTs 1b and 2 were significantly more common in female, older, nosocomially-infected patients, while GTs 1a, 3 and 4 were more frequent in male, younger patients infected by tattooing, drug consume, and/or sexual practices. In infections acquired by drug consume, GTs 1a (35.0%) and 3 (28.1%) prevailed. In infections related to sexual practices lower proportion of GT3 (14.0%) and higher of GT4 (20.2%) were detected. GT4 was mostly abundant in MSM (29.6%). HIV coinfection was significantly associated with higher proportions GTs 1a and 4 (42.5% and 19.3%, respectively). CONCLUSION: Genotype prevalence evolves and correlates to epidemiological factors. Continuous surveillance is necessary to better assess hepatitis C infection in Europe and to take appropriate actionspt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Clin Virol. 2016 Aug;81:82-9. doi: 10.1016/j.jcv.2016.05.010pt_PT
dc.identifier.doi10.1016/j.jcv.2016.05.010pt_PT
dc.identifier.issn10.1016/j.jcv.2016.05.010
dc.identifier.urihttp://hdl.handle.net/10400.26/30652
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://doi.org/10.1016/j.jcv.2016.05.010pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectGenotypept_PT
dc.subjectHCVpt_PT
dc.subjectHepatitis C viruspt_PT
dc.subjectMolecular epidemiologypt_PT
dc.subjectTransmissionpt_PT
dc.titleNew findings in HCV genotype distribution in selected West European, Russian and Israeli regionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage89pt_PT
oaire.citation.startPage82pt_PT
oaire.citation.titleJournal of Clinical Virologypt_PT
oaire.citation.volume81pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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