Publication
Production and characterization of spray-dried theophylline powders prepared from fresh milk for potential use in paediatrics
| dc.contributor.author | Aguiar, João P. | |
| dc.contributor.author | Fernandes, Tânia A. P. | |
| dc.contributor.author | Nese, Carlotta | |
| dc.contributor.author | Fernandes, Ana I. | |
| dc.contributor.author | Pinto, João F. | |
| dc.date.accessioned | 2017-11-24T15:12:56Z | |
| dc.date.available | 2018-06-01T00:30:12Z | |
| dc.date.issued | 2017-05 | |
| dc.description | "This is the accepted version of the following article: Production and characterization of spray-dried theophylline powders prepared from fresh milk for potential use in paediatrics (2017). J Pharm Pharmacol, 69: 554–566, which has been published in final form at http://dx.doi.org/10.1111/jphp.12612 . This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [http://olabout.wiley.com/WileyCDA/Section/id-820227.html]." | pt_PT |
| dc.description.abstract | Objective: This work evaluates the potential of using fresh milk to deliver theophylline to children. | pt_PT |
| dc.description.abstract | Methods: Theophylline–fresh milk systems were prepared using different solids ratios (0 : 1–1 : 0) and three fat contents in commercial milks (low, medium and high), which were spray-dried at different inlet air temperatures (Tinlet – 105, 130 and 150 °C). The process was evaluated for yield and the resulting powders for moisture content (MC), particle size and shape, density and wettability. Theophylline–milk potential interactions (differential scanning calorimetry (DSC) and FT-IR) and chemical (theophylline content) and microbiological stability of powders (shelf and in-use) were also evaluated. | pt_PT |
| dc.description.abstract | Key Findings: The production yield (13.6–76.0%), MC (0.0–10.3%) and contact angles in water (77.29–93.51°) were significantly (P < 0.05) affected by Tinlet, but no differences were found concerning the mean particle size (3.0–4.3 μm) of the different powders. The milk fat content significantly (P < 0.05) impacted on the density (1.244–1.552 g/cm3). Theophylline content remained stable after 6 months of storage, before extemporaneous reconstitution. After reconstitution in water, low-fat milk samples (stored at 4 °C) met the microbial pharmacopoeia criteria for up to 7 days. No theophylline–milk components interaction was observed. | pt_PT |
| dc.description.abstract | Conclusion: Spray-dried milk-composed powders may be used as vehicles for theophylline delivery in paediatrics following further characterization and in-vivo evaluation. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Aguiar, J. P., Fernandes, T. A. P., Nese, C., Fernandes, A. I. and Pinto, J. F. (2017), Production and characterization of spray-dried theophylline powders prepared from fresh milk for potential use in paediatrics. J Pharm Pharmacol, 69: 554–566. doi:10.1111/jphp.12612 | pt_PT |
| dc.identifier.doi | 10.1111/jphp.12612 | pt_PT |
| dc.identifier.issn | 0022-3573 | |
| dc.identifier.issn | 2042-7158 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/19499 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Wiley | pt_PT |
| dc.relation | Powdered medicinal milks for oral delivery of drugs in paediatrics (MedMilk) | |
| dc.relation.publisherversion | http://dx.doi.org/10.1111/jphp.12612 | pt_PT |
| dc.subject | Extemporaneous-preparation | pt_PT |
| dc.subject | Milk | pt_PT |
| dc.subject | Solid-oral-drug-delivery | pt_PT |
| dc.subject | Paediatrics | pt_PT |
| dc.subject | Spray-drying | pt_PT |
| dc.subject | Theophylline | pt_PT |
| dc.title | Production and characterization of spray-dried theophylline powders prepared from fresh milk for potential use in paediatrics | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Powdered medicinal milks for oral delivery of drugs in paediatrics (MedMilk) | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-FTO%2F1057%2F2012/PT | |
| oaire.citation.endPage | 566 | pt_PT |
| oaire.citation.startPage | 554 | pt_PT |
| oaire.citation.title | Journal of Pharmacy and Pharmacology | pt_PT |
| oaire.citation.volume | 69(5) | pt_PT |
| oaire.fundingStream | 3599-PPCDT | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.embargofct | Política de copyright do editor | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isProjectOfPublication | a0df4380-9007-4eab-b38d-fd36fc6745f6 | |
| relation.isProjectOfPublication.latestForDiscovery | a0df4380-9007-4eab-b38d-fd36fc6745f6 |