Publicação
Treatment of periodontitis and C-reactive protein : a systematic review and meta-analysis of randomized clinical trials
| datacite.subject.fos | Ciências Médicas::Ciências da Saúde | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Luthra, Shailly | |
| dc.contributor.author | Orlandi, Marco | |
| dc.contributor.author | Hussain, Syed Basit | |
| dc.contributor.author | Leira, Yago | |
| dc.contributor.author | Botelho, João | |
| dc.contributor.author | Machado, Vanessa | |
| dc.contributor.author | Mendes, José João | |
| dc.contributor.author | Marletta, Debora | |
| dc.contributor.author | Harden, Simon | |
| dc.contributor.author | D'Aiuto, Francesco | |
| dc.date.accessioned | 2026-03-17T11:27:49Z | |
| dc.date.available | 2026-03-17T11:27:49Z | |
| dc.date.issued | 2023-01 | |
| dc.description.abstract | Background Systemic inflammation is implicated in the onset and progression of several chronic diseases. Periodontitis is a potential trigger of systemic inflammation. Purpose: To comprehensively appraise all the evidence on the effects of the treatment of periodontitis on systemic inflammation assessed by serum C-reactive protein (CRP) levels. Data Sources: Six electronic databases were searched up to 10 February 2022 to identify and select articles in English language only. Study Selection: Twenty-six randomized controlled clinical trials reporting changes amongst 2579 participants about CRP levels at 6 months or more after treatment. Data Extraction: Two reviewers independently extracted data and rated the quality of studies. Meta-analyses were performed using random and fixed effect models. Risk of Bias: Risk of bias (RoB 2.0 tool) and quality of evidence (GRADEpro GDT tool) analyses were completed. Data Synthesis: Treatment of periodontitis reduced CRP levels by 0.69 mg/L (95% confidence interval: −0.97 to −0.40) after 6 months, but limited evidence was retrieved from studies with longer follow-ups. Similar findings were observed in participants with other co-morbidities in addition to periodontitis. Greatest reductions were observed in participants with concentrations of CRP >3 mg/L at baseline. Limitations: High level of heterogeneity. Conclusions: Treatment of periodontitis reduces serum CRP levels (up to 6 months follow-up) to a degree equivalent to that observed after traditional lifestyle or drug interventions. This evidence supports a causal association between periodontitis and systemic inflammation. | eng |
| dc.identifier.citation | Luthra, S., Orlandi, M., Hussain, S. B., Leira, Y., Botelho, J., Machado, V., Mendes, J. J., Marletta, D., Harden, S., & D'Aiuto, F. (2023). Treatment of periodontitis and C-reactive protein: A systematic review and meta-analysis of randomized clinical trials. Journal of Clinical Periodontology, 50(1), 45–60. https://doi.org/10.1111/jcpe.13709 | |
| dc.identifier.doi | 10.1111/jcpe.13709 | |
| dc.identifier.issn | 1600-051X | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/62218 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Wiley | |
| dc.relation.hasversion | https://doi.org/10.1111/jcpe.13709 | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | biomarkers | |
| dc.subject | CRP | |
| dc.subject | inflammation | |
| dc.subject | meta-analysis | |
| dc.subject | periodontitis | |
| dc.title | Treatment of periodontitis and C-reactive protein : a systematic review and meta-analysis of randomized clinical trials | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 60 | |
| oaire.citation.issue | 1 | |
| oaire.citation.startPage | 45 | |
| oaire.citation.title | Journal of Clinical Periodontology | |
| oaire.citation.volume | 50 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |