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Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries

2019-08Journal article Open access
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dc.contributor.authorPerdigão, João
dc.contributor.authorSilva, Carla
dc.contributor.authorDiniz, Jaciara
dc.contributor.authorPereira, Catarina
dc.contributor.authorMachado, Diana
dc.contributor.authorRamos, Jorge
dc.contributor.authorSilva, Hugo
dc.contributor.authorAbilleira, Fernanda
dc.contributor.authorBrum, Clarice
dc.contributor.authorReis, Ana J.
dc.contributor.authorMacedo, Maíra
dc.contributor.authorScaini, João L.
dc.contributor.authorSilva, Ana B.
dc.contributor.authorEsteves, Leonardo
dc.contributor.authorMacedo, Rita
dc.contributor.authorMaltez, Fernando
dc.contributor.authorClemente, Sofia
dc.contributor.authorCoelho, Elizabeth
dc.contributor.authorPortugal, Isabel Portugal
dc.date.accessioned2019-12-13T12:59:07Z
dc.date.available2019-12-13T12:59:07Z
dc.date.issued2019-08
dc.descriptionThis is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).pt_PT
dc.description.abstractTuberculosis (TB) remains a major health problem within the Community of Portuguese Language Speaking Countries (CPLP). Despite the marked variation in TB incidence across its member-states and continued human migratory flux between countries, a considerable gap in the knowledge on the Mycobacterium tuberculosis population structure and strain circulation between the countries still exists. To address this, we have assembled and analysed the largest CPLP M. tuberculosis molecular and drug susceptibility dataset, comprised by a total of 1447 clinical isolates, including 423 multidrug-resistant isolates, from five CPLP countries. The data herein presented reinforces Latin American and Mediterranean (LAM) strains as the hallmark of M. tuberculosis populational structure in the CPLP coupled with country-specific differential prevalence of minor clades. Moreover, using high-resolution typing by 24-loci MIRU-VNTR, six cross-border genetic clusters were detected, thus supporting recent clonal expansion across the Lusophone space. To make this data available to the scientific community and public health authorities we developed CPLP-TB (available at http://cplp-tb.ff.ulisboa.pt), an online database coupled with web-based tools for exploratory data analysis. As a public health tool, it is expected to contribute to improved knowledge on the M. tuberculosis population structure and strain circulation within the CPLP, thus supporting the risk assessment of strain-specific trends.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInfect Genet Evol. 2019 Aug;72:44-58. doi: 10.1016/j.meegid.2018.03.011pt_PT
dc.identifier.doi10.1016/j.meegid.2018.03.011pt_PT
dc.identifier.issn1567-1348
dc.identifier.urihttp://hdl.handle.net/10400.26/30477
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://doi.org/10.1016/j.meegid.2018.03.011pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDrug resistancept_PT
dc.subjectLAMpt_PT
dc.subjectMIRU-VNTRpt_PT
dc.subjectMigrationpt_PT
dc.subjectMycobacteriapt_PT
dc.subjectSpoligotypingpt_PT
dc.subjectTuberculosispt_PT
dc.titleClonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countriespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage58pt_PT
oaire.citation.startPage44pt_PT
oaire.citation.titleInfection, Genetics and Evolutionpt_PT
oaire.citation.volume72pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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