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An umbrella review of the evidence linking oral health and systemic noncommunicable diseases

2022-12Contribution to journal Open access
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorBotelho, João
dc.contributor.authorMascarenhas, Paulo
dc.contributor.authorViana, João
dc.contributor.authorProença, Luís
dc.contributor.authorOrlandi, Marco
dc.contributor.authorLeira, Yago
dc.contributor.authorChambrone, Leandro
dc.contributor.authorMendes, José João
dc.contributor.authorMachado, Vanessa
dc.date.accessioned2025-10-22T11:16:12Z
dc.date.available2025-10-22T11:16:12Z
dc.date.issued2022-12
dc.description.abstractOral diseases are highly prevalent worldwide. Recent studies have been supporting a potential bidirectional association of oral diseases with systemic noncommunicable diseases (NCDs). Available evidence supports that people with NCDs have a greater prevalence of oral diseases particularly those with limited ability of oral self-care. Regarding the reverse relationship, the lines of evidence pointing out NCDs as putative risk factors for oral diseases have increased significantly but not with a consistent agreement. This umbrella review of meta-analyses appraises the strength and validity of the evidence for the association between oral health and systemic health (registered at PROSPERO, ID: CRD42022300740). An extensive search included systematic reviews that have provided meta-analytic estimates on the association of oral diseases with NCDs. The overall strength of evidence was found to be unfavorable and with methodological inconsistencies. Twenty-eight NCDs were strongly associated with oral diseases. Among those NCDs are five types of cancer, diabetes mellitus, cardiovascular diseases, depression, neurodegenerative conditions, rheumatic diseases, inflammatory bowel disease, gastric helicobacter pylori, obesity, and asthma. According to fail-safe number statistics, the evidence levels are unlikely to change in the future, indicating a fairly robust consistency.eng
dc.identifier.citationBotelho, J., Mascarenhas, P., Viana, J. et al. An umbrella review of the evidence linking oral health and systemic noncommunicable diseases. Nat Commun 13, 7614 (2022). https://doi.org/10.1038/s41467-022-35337-8
dc.identifier.doi10.1038/s41467-022-35337-8
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/10400.26/59342
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Nature
dc.relation.hasversionhttps://doi.org/10.1038/s41467-022-35337-8
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDental diseases
dc.subjectDiagnostic markers
dc.subjectEpidemiology
dc.subjectHealth care
dc.titleAn umbrella review of the evidence linking oral health and systemic noncommunicable diseaseseng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.startPage7614
oaire.citation.titleNature Communications
oaire.citation.volume13
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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