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Controvérsias acerca da utilização de fibrina rica em plaquetas (PRF) em periodontologia
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Abstract(s)
A utilização de fibrina rica em plaquetas (PRF) está a despertar um interesse considerável no campo da medicina dentária, particularmente em periodontologia. No entanto, vários estudos recentes puseram em causa a sua eficácia em determinadas aplicações específicas.
No contexto da reabilitação de maxilas posteriores edêntulas com implantes dentários, foi demonstrado que a utilização de PRF não conduziu a melhores resultados três meses após a colocação do implante (Karagah et al., 2022).
Além disso, a PRF não mostrou nenhum benefício superior em termos de redução da perda óssea marginal em torno dos implantes(Naeimi Darestani et al., 2023).
Para esclarecer os benefícios bucodentários reais e as prioridades para os pacientes, quando são aplicados produtos derivados do sangue, devem ser realizados mais estudos in vitro e in vivo sobre a atividade do PRF na biologia das células dentárias(Farshidfar et al., 2022).
Noutro contexto relacionado com o recobrimento radicular dentário, tradicionalmente realizado com enxertos de tecido conjuntivo sub-epitelial, alguns estudos têm considerado a utilização de fibrina rica em plaquetas (PRF) devido ao seu potencial regenerativo e factores de crescimento. No entanto, apesar da promessa inicial, as comparações entre a PRF e os enxertos convencionais mostraram limitações em termos de eficácia em favor da técnica padrão ouro: enxerto de tecido conjuntivo subepitelial (Louis et al., 2023).
Além disso, se compararmos os efeitos do PRF e das injecções de ácido hialorônico no fenótipo gengival fino, verificamos um aumento da GT(espessura gengival) e da KTW (largura do tecido queratinizado), sem diferença estatisticamente significativa entre os dois métodos, o que lança dúvidas sobre a eficácia da PRF (Faour et al., 2022).
Resumindo, embora a PRF esteja a despertar interesse como potencial ferramenta em periodontologia, estudos recentes têm lançado dúvidas sobre a sua eficácia em determinadas situações específicas.
O presente trabalho consiste numa revisão da literatura sobre PRF(fibrina rica em plaquetas), focando-se essencialmente nas controvérsias da utilização do PRF na periodontologia.
The use of Platelet-Rich Fibrin (PRF) has sparked considerable interest in the field of dentistry, particularly in periodontology. However, several recent studies have raised questions about its effectiveness in certain specific applications. In the context of rehabilitating posterior edentulous maxillae with dental implants, it has been shown that the use of PRF did not lead to better outcomes three months after implant placement (Karagah et al, 2022). Furthermore, PRF has not shown any superior benefit in terms of reducing marginal bone loss around implants (Naeimi Darestani et al, 2023). To clarify the actual oral health benefits and priorities for patients when blood-derived products are applied, further in vitro and in vivo studies on PRF activity in dental cell biology should be conducted (Farshidfar et al, 2022). In another context related to dental root coverage, traditionally performed with subepithelial connective tissue grafts, some studies have considered the use of Platelet-Rich Fibrin (PRF) due to its regenerative potential and growth factors. However, despite the initial promise, comparisons between PRF and conventional grafts have shown limitations in terms of efficacy in favor of the gold standard technique: subepithelial connective tissue graft (Louis et al, 2023). Furthermore, when comparing the effects of PRF and hyaluronic acid injections on thin gingival phenotype, an increase in GT (gingival thickness) and KTW (keratinized tissue width) is observed, with no statistically significant difference between the two methods, casting doubts on the effectiveness of the widely touted PRF (Faour et al, 2022). In summary, while PRF is gaining interest as a potential tool in periodontology, recent studies have raised doubts about its effectiveness in certain specific situations. The present study consists of a literature review on PRF (Platelet-Rich Fibrin), focusing primarily on the controversies surrounding its use in periodontology.
The use of Platelet-Rich Fibrin (PRF) has sparked considerable interest in the field of dentistry, particularly in periodontology. However, several recent studies have raised questions about its effectiveness in certain specific applications. In the context of rehabilitating posterior edentulous maxillae with dental implants, it has been shown that the use of PRF did not lead to better outcomes three months after implant placement (Karagah et al, 2022). Furthermore, PRF has not shown any superior benefit in terms of reducing marginal bone loss around implants (Naeimi Darestani et al, 2023). To clarify the actual oral health benefits and priorities for patients when blood-derived products are applied, further in vitro and in vivo studies on PRF activity in dental cell biology should be conducted (Farshidfar et al, 2022). In another context related to dental root coverage, traditionally performed with subepithelial connective tissue grafts, some studies have considered the use of Platelet-Rich Fibrin (PRF) due to its regenerative potential and growth factors. However, despite the initial promise, comparisons between PRF and conventional grafts have shown limitations in terms of efficacy in favor of the gold standard technique: subepithelial connective tissue graft (Louis et al, 2023). Furthermore, when comparing the effects of PRF and hyaluronic acid injections on thin gingival phenotype, an increase in GT (gingival thickness) and KTW (keratinized tissue width) is observed, with no statistically significant difference between the two methods, casting doubts on the effectiveness of the widely touted PRF (Faour et al, 2022). In summary, while PRF is gaining interest as a potential tool in periodontology, recent studies have raised doubts about its effectiveness in certain specific situations. The present study consists of a literature review on PRF (Platelet-Rich Fibrin), focusing primarily on the controversies surrounding its use in periodontology.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Fibrina rica em plaquetas Regeneração Periodonto Controvérsias