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Publication
A importância dos ritmos biológicos nas doenças cardiovasculares e no seu tratamento farmacológico
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Abstract(s)
Apesar de avanços consideráveis no tratamento farmacológico da hipertensão, esta doença continua a afetar aproximadamente um terço da população adulta mundial e é uma das principais causas de morte prematura. Mudanças no estilo de vida (exercício regular, controlo do peso corporal e hábitos alimentares saudáveis) têm sido benéficas na prevenção de riscos e na melhoria da saúde vascular. No entanto, como a hipertensão
permanece com prevalência e incidência elevada, são necessárias outras vias de pesquisa na prevenção e tratamento das doenças cardiovasculares. Uma crescente quantidade de informação sugere que os ritmos circadianos têm um impacto na fisiologia dos órgãos do corpo humano. Os relógios moleculares também desempenham um papel crucial nos parâmetros cardíacos vitais e na pressão arterial.
Esses ritmos também mostram influenciar a farmacocinética e a farmacodinâmica dos agentes terapêuticos e eventualmente aumentam a sua eficácia.
Para a realização deste trabalho, ou seja, avaliar o papel e importância dos ritmos biológicos nas doenças cardiovasculares e o seu tratamento farmacológico, será realizada uma revisão bibliográfica utilizando vários motores de busca em linha, ou seja, Pubmed, Google Scholar e ScienceDirect, utilizando as seguintes palavras-chave: Relógios circadianos, Ritmos circadianos, Cronoterapia, Pressão sanguínea.
Despite considerable advances in the pharmacological treatment of hypertension, this disease continues to affect approximately on-third of the world’s adult population and is one of the leading causes of premature death. Lifestyle changes (regular exercise, weight control, and healthy eating habits) have been beneficial in preventing risks and improving vascular health. However, as hypertension remains prevalent and with high incidence, other avenues of research are needed on the prevention and treatment of cardiovascular diseases. A growning body of evidence suggests that circadian rhythms impact the physiology of humam organ systems. Molecular clocks also play a crucial role in vital cardiac parameters and blood pressure. These rhythms also appear to influence the pharmacokinetics and pharmacodynamics of therapeutic agents and eventually enhance their efficacy. To carry out this work, i.e., evaluate knowledge about the role and importance of biological rhythms in cardiovascular diseases and their pharmacological treatment, a literature review will be conducted using various online search engines, namely PubMed, Google Scholar, ScienceDirect, employing the following keywords: Ciscadian clocks, Circadian rhythms, Chronotherapy, Blood Pressure
Despite considerable advances in the pharmacological treatment of hypertension, this disease continues to affect approximately on-third of the world’s adult population and is one of the leading causes of premature death. Lifestyle changes (regular exercise, weight control, and healthy eating habits) have been beneficial in preventing risks and improving vascular health. However, as hypertension remains prevalent and with high incidence, other avenues of research are needed on the prevention and treatment of cardiovascular diseases. A growning body of evidence suggests that circadian rhythms impact the physiology of humam organ systems. Molecular clocks also play a crucial role in vital cardiac parameters and blood pressure. These rhythms also appear to influence the pharmacokinetics and pharmacodynamics of therapeutic agents and eventually enhance their efficacy. To carry out this work, i.e., evaluate knowledge about the role and importance of biological rhythms in cardiovascular diseases and their pharmacological treatment, a literature review will be conducted using various online search engines, namely PubMed, Google Scholar, ScienceDirect, employing the following keywords: Ciscadian clocks, Circadian rhythms, Chronotherapy, Blood Pressure
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Relógios circadianos Ritmos circadianos Cronoterapia Pressão sanguínea