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Influência da ação bacteriana na corrosão do titânio implantar: uma revisão sistemática e meta-análise
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Abstract(s)
Objetivo: A análise da evidência científica mais atual com enfoque na influência da ação microbiana na ocorrência de corrosão na superfície implantar.
Materiais e Métodos: Esta revisão seguiu as direções PRISMA, que reporta os principais itens a considerar numa revisão sistemática e meta-análise. A questão clínica formulada num formato PICO foi: Em ligas de titânio/titânio ou outro material implantar similar quando imersos em meios bacterianos e/ou acidogénicos (representativos de infeção oral), comparativamente a grupos controlo (representativos de ambiente oral saudável), ocorre (maior) corrosão? Para isso recorreu-se às bases de dados PubMed/MEDLINE, B-On, Web of Science e Cochrane Library, fazendo uso de diferentes termos MESH, em diferentes combinações e, de uma pesquisa manual da literatura existente com respeito a este assunto.
Resultados: A pesquisa permitiu reunir um total de 1001 artigos, dos quais, apenas 25 foram incluídos na presente revisão. A grande maioria dos estudos observou uma maior ocorrência de corrosão e libertação de iões em meios mais acídicos e/ou com presença de lipossacáridos ou bactérias. A meta-regressão realizada reportou maior comportamento corrosivo em pH’s mais afastados dos fisiológicos, tanto acídicos como básicos.
Conclusões: As bactérias exercem de facto, direta ou indiretamente, influência na ocorrência de corrosão do titânio implantar. Contudo, são necessários mais estudos clínicos randomizados, reforçando-se também a necessidade de esses estudos reportarem de forma adequada o historial clínico dos pacientes.
Objective: The analysis of the most current scientific evidence focusing on the influence of microbial action on the occurence of corrosion on the implant surface. Materials and Methods: This review followed the PRISMA directions, which reports the main items to consider in a systematic review and meta-analysis. The clinical question formulated, in a PICO format, was: In titanium / titanium alloys or other similar implant material when immersed in bacterial and / or acidogenic media (representative of oral infection), compared to control groups (representative of healthy oral environment), occurs (major) corrosion? For that, we used the databases PubMed / MEDLINE, B-On, Web of Science and Cochrane Library, using different MESH terms, in different combinations and a manual search of the literature with respect to this subject. Results: The research allowed to gather a total of 1001 articles, of which, only 25 were included in this review. The vast majority of studies have observed a greater occurrence of corrosion and release of ions in more acidic media and / or with the presence of liposaccharides or bacteria. The meta-regression performed reported greater corrosive behavior at pH's that were further from the physiological ones, both acidic and basic. Conclusions: Bacteria do, directly or indirectly, influence the occurrence of corrosion of the implant titanium. However, more randomized clinical studies are needed, reinforcing also the need for these studies to adequately report the clinical history of patients.
Objective: The analysis of the most current scientific evidence focusing on the influence of microbial action on the occurence of corrosion on the implant surface. Materials and Methods: This review followed the PRISMA directions, which reports the main items to consider in a systematic review and meta-analysis. The clinical question formulated, in a PICO format, was: In titanium / titanium alloys or other similar implant material when immersed in bacterial and / or acidogenic media (representative of oral infection), compared to control groups (representative of healthy oral environment), occurs (major) corrosion? For that, we used the databases PubMed / MEDLINE, B-On, Web of Science and Cochrane Library, using different MESH terms, in different combinations and a manual search of the literature with respect to this subject. Results: The research allowed to gather a total of 1001 articles, of which, only 25 were included in this review. The vast majority of studies have observed a greater occurrence of corrosion and release of ions in more acidic media and / or with the presence of liposaccharides or bacteria. The meta-regression performed reported greater corrosive behavior at pH's that were further from the physiological ones, both acidic and basic. Conclusions: Bacteria do, directly or indirectly, influence the occurrence of corrosion of the implant titanium. However, more randomized clinical studies are needed, reinforcing also the need for these studies to adequately report the clinical history of patients.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Titânio Implantes dentários Corrosão Bactérias