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Canabinóides e o sistema endocanabinóide: uma nova era na terapêutica? Conhecimentos atuais e perspetivas futuras
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Abstract(s)
A descoberta do 9-tetrahidrocanabinol (9-THC) como o principal componente psicoativo da canábis (marijuana), a clonagem dos recetores canabinóides CB1R e CB2R e a identificação dos endocanabinóides (mediadores lipídicos) como seus ligandos endógenos estimularam uma investigação aprofundada sobre o papel do sistema canabinóide na regulação sináptica do SNC. Além disso, os canabinóides também
modulam as vias de transdução de sinal e exercem efeitos profundos em locais periféricos e têm um papel central na manutenção da homeostasia. Estão envolvidos na regulação da dor, da inflamação, do apetite, do sono, do humor, da cognição, das emoções e adição e na regulação endócrina e metabólica, entre outras. O conhecimento deste sistema levou à exploração da utilização da canábis em múltiplas condições patológicas periféricas e centrais onde as opções terapêuticas continuam limitadas.
The discovery of 9-tetrahydrocannabinol (9-THC) as the main psychoactive component of cannabis (marijuana), the cloning of the cannabinoid receptors CB1R and CB2R. and the identification of endocannabinoids (lipid mediators) as their endogenous ligands have stimulated in-depth research into the role of the cannabinoid system in synaptic regulation of the CNS. In addition, cannabinoids also modulate signal transduction pathways and exert profound effects at peripheral sites. They are involved in the regulation of pain, inflammation, appetite, sleep, mood, cognition, emotions and addiction and in endocrine and metabolic regulation, among others. Knowledge of this system has led to the exploration of the use of cannabis in multiple peripheral and central pathological conditions where therapeutic options remain limited.
La découverte du 9-tétrahydrocannabinol (9-THC) comme principal composant psychoactif du cannabis (marijuana), le clonage des récepteurs cannabinoïdes CB1R et CB2R et l'identification des endocannabinoïdes (médiateurs lipidiques) comme leurs ligands endogènes ont stimulé des recherches approfondies sur le rôle du système cannabinoïde dans la régulation synaptique du SNC. En outre, les cannabinoïdes modulent également les voies de transduction du signal et exercent des effets profonds sur les sites périphériques. Ils sont impliqués dans la régulation de la douleur, de l'inflammation, de l'appétit, du sommeil, de l'humeur, de la cognition, des émotions et de la dépendance, ainsi que dans la régulation endocrinienne et métabolique, entre autres. La connaissance de ce système a conduit à l'exploration de l'utilisation du cannabis dans de multiples conditions pathologiques périphériques et centrales où les options thérapeutiques restent limitées.
The discovery of 9-tetrahydrocannabinol (9-THC) as the main psychoactive component of cannabis (marijuana), the cloning of the cannabinoid receptors CB1R and CB2R. and the identification of endocannabinoids (lipid mediators) as their endogenous ligands have stimulated in-depth research into the role of the cannabinoid system in synaptic regulation of the CNS. In addition, cannabinoids also modulate signal transduction pathways and exert profound effects at peripheral sites. They are involved in the regulation of pain, inflammation, appetite, sleep, mood, cognition, emotions and addiction and in endocrine and metabolic regulation, among others. Knowledge of this system has led to the exploration of the use of cannabis in multiple peripheral and central pathological conditions where therapeutic options remain limited.
La découverte du 9-tétrahydrocannabinol (9-THC) comme principal composant psychoactif du cannabis (marijuana), le clonage des récepteurs cannabinoïdes CB1R et CB2R et l'identification des endocannabinoïdes (médiateurs lipidiques) comme leurs ligands endogènes ont stimulé des recherches approfondies sur le rôle du système cannabinoïde dans la régulation synaptique du SNC. En outre, les cannabinoïdes modulent également les voies de transduction du signal et exercent des effets profonds sur les sites périphériques. Ils sont impliqués dans la régulation de la douleur, de l'inflammation, de l'appétit, du sommeil, de l'humeur, de la cognition, des émotions et de la dépendance, ainsi que dans la régulation endocrinienne et métabolique, entre autres. La connaissance de ce système a conduit à l'exploration de l'utilisation du cannabis dans de multiples conditions pathologiques périphériques et centrales où les options thérapeutiques restent limitées.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Sistema endocanabinóide (SEC) Canabinóides Canábis medicinal Distúrbios neurológicos Aplicações terapêuticas