Publicação
Influence of local and systemic antibiotics in non-surgical peri-implantitis treatment : a systematic review and meta-analysis update
| datacite.subject.fos | Ciências Médicas::Ciências da Saúde | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Meném, Madalena | |
| dc.contributor.author | Estácio, Catarina | |
| dc.contributor.author | Mascarenhas, Paulo | |
| dc.contributor.author | Santos, Alexandre | |
| dc.date.accessioned | 2026-05-12T14:08:05Z | |
| dc.date.available | 2026-05-12T14:08:05Z | |
| dc.date.issued | 2025-11 | |
| dc.description.abstract | Background: Adjunctive antibiotics are frequently used alongside mechanical debridement (MD) for peri-implantitis, yet their additional clinical benefit remains uncertain. Objective: To systematically assess whether adding local or systemic antibiotics to non-surgical MD improves clinical outcomes in peri-implantitis. Methods: The review protocol was registered in PROSPERO (CRD42022380401). We included randomised controlled trials (RCTs) involving peri-implantitis patients treated with MD plus local or systemic antibiotics, compared to MD alone, with at least 3 months of follow-up. Searches were conducted in PubMed, Cochrane Library, LILACS, Web of Science, and Embase up to 9 April 2025. Eleven RCTs (634 patients) were included in the qualitative synthesis. The Cochrane RoB 2.0 tool evaluated the risk of bias. Random-effects meta-analyses of data from 10 studies, adjusting results to an equivalent 6-month follow-up time-frame, assessed treatment efficacy based on changes in probing pocket depth (PPD) and bleeding on probing (BoP), the primary outcomes. Meta-regressions examined the influence of mean patient age and implant-to-patient ratio on adjusted outcomes. Results: Systemic antibiotics resulted in generally greater PPD reduction and BoP reduction over MD alone or plus chlorhexidine, with the greatest benefits observed in amoxicillin-based multi-agent regimens and longer follow-up duration. Comparatively, local antimicrobial adjuncts performed less effectively on PPD reduction. No implant losses were reported, and adverse events were rare. Limitations: Some included trials had a high risk of bias and considerable heterogeneity. Follow-up was limited to the short term, and definitions of clinical “success” varied across studies. Conclusions: Adjunctive systemic antibiotics, particularly amoxicillin-based combinations, substantially improve short-term clinical outcomes of non-surgical peri-implantitis treatment compared to MD alone. Nevertheless, given the variability in study quality and potential risks associated with antibiotic use, their application should be judicious. Further long-term RCTs are warranted to confirm sustained efficacy and safety. | eng |
| dc.identifier.citation | Meném M, Estácio C, Mascarenhas P, Santos A. Influence of Local and Systemic Antibiotics in Non-Surgical Peri-Implantitis Treatment: A Systematic Review and Meta-Analysis Update. Applied Sciences. 2025; 15(21):11422. https://doi.org/10.3390/app152111422 | |
| dc.identifier.doi | 10.3390/app152111422 | |
| dc.identifier.issn | 2076-3417 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/63078 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation.hasversion | https://doi.org/10.3390/app152111422 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | dental implants | |
| dc.subject | peri-implantitis | |
| dc.subject | periodontitis | |
| dc.subject | peri-implantitis therapy | |
| dc.subject | peri-implantitis treatment | |
| dc.title | Influence of local and systemic antibiotics in non-surgical peri-implantitis treatment : a systematic review and meta-analysis update | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 21 | |
| oaire.citation.startPage | 11422 | |
| oaire.citation.title | Applied Sciences | |
| oaire.citation.volume | 15 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |