Emerging patterns in HIV integrase resistance

We assessed integrase resistance in 837 treatment-experienced people with HIV (PWH) with virological failure (2022–2024) in Portugal. Major resistance mutations were found in 5.5%, with N155H and R263K being the most common. Resistance was more frequent in non-B subtypes and often co-occurred with resistance to other antiretroviral classes. Though prevalence remains low, the findings highlight the need for continued surveillance to inform treatment decisions, especially as integrase inhibitors like dolutegravir, bictegravir and cabotegravir become more widely used.

Palavras-chave

HIV integrase resistance patterns

URI

http://hdl.handle.net/10400.26/63019

Citação

Veloso, Margarida; Ribeiro, Marta; Cabanas, Joaquim; Gonçalves, Fátima; Fernandes, Sandra; Diogo, Isabel; Costa, Inês; Pimentel, Victor; Pingarilho, Marta; Abecasis, Ana; Gomes, Perpétua. Emerging patterns in HIV integrase resistance. AIDS 39(15):p 2324-2327, December 01, 2025. | DOI: 10.1097/QAD.0000000000004322

Editora

Wolters Kluwer

DOI

10.1097/QAD.0000000000004322

Coleções

EM - Artigos Científicos

Licença CC

cclicense-by-nc-nd

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