Loading...
Publication
Feline Mammary Tumors Of Rare And Uncommon Histological Types
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 852.91 KB | Adobe PDF |
Advisor(s)
Abstract(s)
Os tumores mamários são uma das neoplasias mais comuns em gatas. Alguns subtipos histológicos malignos como os carcinomas tubulares, tubulopapilares e sólidos são comuns, enquanto outros são considerados tumores mamários raros e incomuns (RUMT). Este grupo inclui carcinomas simples (micropapilares e anaplásicos) e de tipo especial (carcinomas adenoscamosos, mucinosos, ricos em lipídios (secretores), de células fusiformes, inflamatórios e carcinossarcomas), e alguns estão associados a um pior prognóstico. No entanto, devido à sua raridade, os dados disponíveis sobre RUMT em animais de companhia, particularmente na gata, são limitados. Assim, os principais objetivos deste estudo foram caracterizar e avaliar a evolução clínica [intervalo livre de doença (DFI) e tempo de sobrevida global (OS)] de gatas com RUMT, através de um estudo retrospetivo multicêntrico.
Foram analisados registos clínicos de gatas com tumores da glândula mamária consultadas em diferentes centros de atendimento médico veterinários de Portugal, entre 2012 e 2023. Animais diagnosticados com RUMT e com informação clínica disponível foram incluídos no estudo. Gatas com RUMT, mas sem informação clínica disponível, com comorbilidades, com história de neoplasia maligna prévia (mamária ou outros tipos), com apenas lesões mamárias não-neoplásicas, tumores mamários benignos ou tumores mamários malignos de tipos histológicos frequentes foram excluídas. Gatas com RUMT e com lesões mamárias não neoplásicas, tumores mamários benignos ou tumores mamários malignos de tipos histológicos frequentes síncronos foram admitidas.
Dezoito gatas com idades compreendidas entre os 3 e 14 anos (média 10.6 anos, DP 2.5 anos) ao diagnóstico foram selecionadas para este estudo, incluindo 7 gatas com carcinomas mucinosos (OS 0.6-14.7 meses, tempo mediano de sobrevivência (MST) 10.1 meses), 6 com carcinomas adenoescamosos (OS 0.7-24.3 meses, MST 6.4 meses), 2 com carcinomas micropapilares invasores (OS 3.5 e 10.5 meses), 2 com carcinossarcomas (OS 1.5 e 4.9 meses), e 1 uma gata com um carcinoma anaplásico (OS 4.9 meses).
A maioria das gatas com RUMT apresentou um DFI e um OS inferiores aos dados reportados em estudos anteriores de gatas com tumores mamários de subtipos histológicos comuns, sugerindo um comportamento biológico mais agressivo e um pior prognóstico dos RUMT nesta espécie. No entanto, no nosso estudo, os tempos de sobrevivência diferiram, em alguns casos substancialmente, entre gatas com tumores de mama do mesmo histotipo tumoral. São necessários estudos prospetivos futuros, envolvendo um maior número de animais, para aumentar o conhecimento das características biológicas, genómicas, moleculares e clínicas destes RUMT em gatas. Além disso, os tumores mamários felinos têm sido descritos como um modelo natural adequado para o estudo do cancro de mama humano. Assim, numa perspetiva de medicina comparada, o conhecimento sobre os RUMT em animais de companhia poderá ser potencialmente útil para a compreensão dos RUMT em humanos.
Mammary tumors are among the most common neoplasias in queens. Malignant histotypes like tubular, tubulopapillary and solid carcinomas are common, while others are considered rare and uncommon mammary tumors (RUMT). This group includes simple carcinomas (micropapillary and anaplastic) and special types (adenosquamous, mucinous, lipid-rich (secretory), spindle cell and inflammatory carcinomas and carcinosarcoma), and some of these tumors are associated with a poor prognosis. Nevertheless, due to their unusualness, data regarding RUMT in veterinary small animal oncology, mainly in felines, is limited. Therefore, the main objectives of this study were to characterize and evaluate the clinical outcome (disease-free interval (DFI) and overall survival (OS) time) of queens with RUMT, through a retrospective multicentric investigation. For that purpose, clinical records of female cats presented with mammary gland tumors to different veterinary medical centers from Portugal, between 2012 and 2023, were analyzed. From this cohort, animals diagnosed with RUMT with available clinical information were included in the study. Queens with RUMT but without available clinical information, with comorbidities, with a history of previous malignant neoplasia (mammary or other types), with only non-neoplastic mammary lesions, benign mammary tumors or malignant mammary tumors of frequent histological types were excluded. Queens with RUMT which also presented non-neoplastic mammary lesions, benign mammary tumors or malignant mammary tumors of common histotypes, simultaneously, were included in the research. Eighteen queens with ages ranging from 3 to 14 years old (mean 10.6 yo, SD 2.5 yo) at diagnosis were selected for the study, including 7 queens with mucinous carcinomas (OS 0.6-14.7 mo, MST 10.1 mo), 6 with adenosquamous carcinomas (OS 0.7-24.3 mo, MST 6.4 mo), 2 with invasive micropapillary carcinomas (OS 3.5 and 10.5 mo), 2 with carcinosarcomas (OS 1.5 and 4.9 mo) and 1 with an anaplastic carcinoma (OS 5.9 mo). Most queens with RUMT had a DFI and an OS inferior to data reported in previous investigations of female cats with mammary tumors of common histological subtypes, suggesting a more aggressive biological behavior and a worse prognosis of RUMT in this species. However, in our study, survival times differed, in some cases substantially, among felines with the same tumor histotype. Future prospective studies, involving a higher number of animals, are necessary to improve knowledge of the biological, genomic, molecular and clinical features of these RUMT in queens. Furthermore, feline mammary tumors have been described as an adequate natural model for the study of human breast cancer. Thus, in a comparative medicine perspective, knowledge regarding RUMT in companion animals could potentially be useful for the understanding of RUMT in humans.
Mammary tumors are among the most common neoplasias in queens. Malignant histotypes like tubular, tubulopapillary and solid carcinomas are common, while others are considered rare and uncommon mammary tumors (RUMT). This group includes simple carcinomas (micropapillary and anaplastic) and special types (adenosquamous, mucinous, lipid-rich (secretory), spindle cell and inflammatory carcinomas and carcinosarcoma), and some of these tumors are associated with a poor prognosis. Nevertheless, due to their unusualness, data regarding RUMT in veterinary small animal oncology, mainly in felines, is limited. Therefore, the main objectives of this study were to characterize and evaluate the clinical outcome (disease-free interval (DFI) and overall survival (OS) time) of queens with RUMT, through a retrospective multicentric investigation. For that purpose, clinical records of female cats presented with mammary gland tumors to different veterinary medical centers from Portugal, between 2012 and 2023, were analyzed. From this cohort, animals diagnosed with RUMT with available clinical information were included in the study. Queens with RUMT but without available clinical information, with comorbidities, with a history of previous malignant neoplasia (mammary or other types), with only non-neoplastic mammary lesions, benign mammary tumors or malignant mammary tumors of frequent histological types were excluded. Queens with RUMT which also presented non-neoplastic mammary lesions, benign mammary tumors or malignant mammary tumors of common histotypes, simultaneously, were included in the research. Eighteen queens with ages ranging from 3 to 14 years old (mean 10.6 yo, SD 2.5 yo) at diagnosis were selected for the study, including 7 queens with mucinous carcinomas (OS 0.6-14.7 mo, MST 10.1 mo), 6 with adenosquamous carcinomas (OS 0.7-24.3 mo, MST 6.4 mo), 2 with invasive micropapillary carcinomas (OS 3.5 and 10.5 mo), 2 with carcinosarcomas (OS 1.5 and 4.9 mo) and 1 with an anaplastic carcinoma (OS 5.9 mo). Most queens with RUMT had a DFI and an OS inferior to data reported in previous investigations of female cats with mammary tumors of common histological subtypes, suggesting a more aggressive biological behavior and a worse prognosis of RUMT in this species. However, in our study, survival times differed, in some cases substantially, among felines with the same tumor histotype. Future prospective studies, involving a higher number of animals, are necessary to improve knowledge of the biological, genomic, molecular and clinical features of these RUMT in queens. Furthermore, feline mammary tumors have been described as an adequate natural model for the study of human breast cancer. Thus, in a comparative medicine perspective, knowledge regarding RUMT in companion animals could potentially be useful for the understanding of RUMT in humans.
Description
Keywords
Carcinoma Felino Intervalo Livre De Doença Oncologia Tumores Mamários Tempo De Sobrevivência Global Disease-Free Interval Feline Mammary Tumors Oncology Overall Survival