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Publication
Padronização dos processos de formulação fitofarmacêutica de forma a reduzir as reprovações de lotes
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| 4.47 MB | Adobe PDF |
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Advisor(s)
Abstract(s)
O estágio desenvolvido no âmbito da unidade curricular de Projeto/Estágio/Dissertação,
intitulado “PADRONIZAÇÃO DOS PROCESSOS DE FORMULAÇÃO
FITOFARMACÊUTICA DE FORMA A REDUZIR AS REPROVAÇÕES DE LOTES”, tem
como principal objetivo analisar e melhorar os processos de produção de pesticidas,
visando diminuir as inconformidades dos lotes. O presente estudo teve como foco a
avaliação minuciosa dos tempos de formulação, conformidade dos lotes e dos fatores
que mais contribuíram para o número de inconformidades, concedendo uma visão
ampla dos motivos que influenciam a qualidade dos pesticidas.
Inicialmente, realizou-se uma análise detalhada aos cadernos de lote de quatro
produtos, onde se verificou uma tendência notória. Os lotes cujos tempos das etapas de
formulação estavam todos dentro de um limite especificado apresentavam uma taxa
mais elevada de conformidade em comparação com os lotes em que os tempos se
encontravam fora desses limites. Contudo, ao adicionar oito produtos à amostragem,
verificou-se que dois apresentaram uma tendência oposta, com uma maior
conformidade nos lotes cujos tempos de formulação estavam fora dos limites definidos.
Estes resultados permitem concluir que, apesar do tempo de formulação ser um fator
relevante para a conformidade dos lotes, outros fatores como a complexidade dos
pesticidas, o número de etapas e a especificidade dos processos dos diversos setores
de produção são essenciais para a conformidade dos lotes.
Outro ponto estudado foi o RFT (Right First Time), isto é, a capacidade de produzir um
produto bem à primeira tentativa. Verificou-se que o RFT é completamente dependente
do tipo de produto que está a ser produzido. Por exemplo, produtos que têm um RFT
elevado e consistente, afetam positivamente as médias semanais.
Por último, verificou-se que o nível de teor da substância ativa é responsável por mais
de metade das inconformidades registadas. Apesar disso, fatores como a granulometria,
viscosidade e humidade foram os que mais contribuíram para estas não conformidades.
Apresentaram-se sugestões de melhoria como a padronização dos procedimentos
operacionais e controlo nas pesagens.
The internship developed during the Project/Internship/Dissertation course unit, entitled "STANDARDIZATION OF THE FORMULATION PROCESSES IN PLANT PROTECTION PRODUCTS TO REDUCE BATCH REJECTIONS", aims primarily to analyze and improve the pesticide production processes, with the goal of reducing batch non-conformities. This study focused on a detailed evaluation of formulation times, batch conformity, and the factors that contributed the most to the number of non-conformities, providing a comprehensive understanding of the reasons influencing the quality of pesticides. Initially, a detailed analysis was conducted on the batch records of four products, where a clear trend was observed. Batches with formulation stage times all within specified limits showed a higher rate of conformity compared to batches where the times were outside these limits. However, when adding eight more products to the sample, it was found that two of them showed an opposite trend, with higher conformity in batches where formulation times were outside the defined limits. These results suggest that although formulation time is a relevant factor for batch conformity, other factors such as the complexity of the pesticides, the number of stages, and the specificity of processes in various production sectors are essential for batch conformity. Another point studied was the RFT (Right First Time), that is, the ability to produce a product correctly on the first attempt. It was observed that RFT is entirely dependent on the type of product being produced. For example, products with high and consistent RFT positively impact the weekly averages. Finally, it was found that the active substance content level is responsible for more than half of the recorded non-conformities; nevertheless, factors such as granulometry, viscosity, and moisture contributed the most to these non-conformities. Improvement suggestions were presented, such as the standardization of operational procedures and control in weighings.
The internship developed during the Project/Internship/Dissertation course unit, entitled "STANDARDIZATION OF THE FORMULATION PROCESSES IN PLANT PROTECTION PRODUCTS TO REDUCE BATCH REJECTIONS", aims primarily to analyze and improve the pesticide production processes, with the goal of reducing batch non-conformities. This study focused on a detailed evaluation of formulation times, batch conformity, and the factors that contributed the most to the number of non-conformities, providing a comprehensive understanding of the reasons influencing the quality of pesticides. Initially, a detailed analysis was conducted on the batch records of four products, where a clear trend was observed. Batches with formulation stage times all within specified limits showed a higher rate of conformity compared to batches where the times were outside these limits. However, when adding eight more products to the sample, it was found that two of them showed an opposite trend, with higher conformity in batches where formulation times were outside the defined limits. These results suggest that although formulation time is a relevant factor for batch conformity, other factors such as the complexity of the pesticides, the number of stages, and the specificity of processes in various production sectors are essential for batch conformity. Another point studied was the RFT (Right First Time), that is, the ability to produce a product correctly on the first attempt. It was observed that RFT is entirely dependent on the type of product being produced. For example, products with high and consistent RFT positively impact the weekly averages. Finally, it was found that the active substance content level is responsible for more than half of the recorded non-conformities; nevertheless, factors such as granulometry, viscosity, and moisture contributed the most to these non-conformities. Improvement suggestions were presented, such as the standardization of operational procedures and control in weighings.
Description
Keywords
Lote Tempo Inconformidade RFT Fatores Batch Time Non-conformity Factors