Publicação
Comparing ready-to-use and powder abobotulinumtoxinA for glabellar lines : a randomized, controlled, triple-blinded clinical trial
| datacite.subject.fos | Ciências Médicas::Ciências da Saúde | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Silva Junior, Silvio Ventura da | |
| dc.contributor.author | Neves, Maria Luiza Boechat Borges | |
| dc.contributor.author | Sanchez-Ayala, Alfonso | |
| dc.contributor.author | Cebola, Pedro Miguel Teixeira Carvas | |
| dc.contributor.author | Carbone, Ana Claudia | |
| dc.contributor.author | Câmara-Souza, Mariana Barbosa | |
| dc.contributor.author | Poluha, Rodrigo Lorenzi | |
| dc.contributor.author | Canales, Giancarlo De la Torre | |
| dc.date.accessioned | 2026-04-30T13:38:47Z | |
| dc.date.available | 2026-04-30T13:38:47Z | |
| dc.date.issued | 2025-07 | |
| dc.description.abstract | Background: Botulinum toxin A (BoNT-A) is the most used procedure to treat glabellar lines; however, limited data exist about the effectiveness of ready-to-use BoNT-A (RTUaboBoNT-A) for this indication. Aims: This study compared the efficacy, durability, and safety of RTUaboBoNT-A for moderate and severe glabellar wrinkles. Methods: This randomized triple-blinded trial included 38 male volunteers aged between 25 and 50 years. Participants were randomly divided into two groups: abobotulinumtoxinA (aboBoNT-A, n = 18) and RTUaboBoNT-A (n = 20). Groups received 10 U for procerus muscle and 20 U for the corrugator muscle. Assessed variables included, electromyography activity (EMG), Merz 5-point glabellar lines scale, FACE-Q appraisal for lines between the eyebrows and Visual Analogue Scale for pain intensity. Assessments were performed before and 1, 2, 3, and 4 months after injections. For differences in EMG and satisfaction scores, the two-way repeated-measures ANOVA and Bonferroni's post hoc analyses were conducted. Wrinkle severity scores were analyzed with the chi-squared test. Results: Inter-group comparisons revealed no significant differences in EMG scores in all assessed periods for the corrugator supercili (p = 0.11) and the procerus muscles (p = 0.93); for severity of glabellar lines, no significant differences were also found in all follow-ups for rest (p = 0.737) and contracted position (p = 0.390), as well as for satisfaction with the treatments. However, the RTUaboBoNT-A group presented higher levels of pain intensity during the injection procedure (p = 0.01). Conclusion: The RTUaboBoNT-A and aboBoNT-A are comparable in efficacy, durability, and safety. | eng |
| dc.identifier.citation | S. V.daSilva Junior, M. L. B.Borges Neves, A.Sanchez-Ayala, et al., “Comparing Ready-to-Use and Powder AbobotulinumtoxinA for Glabellar Lines: A Randomized, Controlled, Triple-Blinded Clinical Trial,” Journal of Cosmetic Dermatology, 24, no. 7 (2025): e70308, https://doi.org/10.1111/jocd.70308. | |
| dc.identifier.doi | 10.1111/jocd.70308 | |
| dc.identifier.issn | 1473-2165 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/62967 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Wiley | |
| dc.relation.hasversion | https://doi.org/10.1111/jocd.70308 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | abobotulinumtoxinA | |
| dc.subject | botulinum toxin type A | |
| dc.subject | glabellar wrinkles | |
| dc.subject | ready-to- use abobotulinumtoxinA | |
| dc.title | Comparing ready-to-use and powder abobotulinumtoxinA for glabellar lines : a randomized, controlled, triple-blinded clinical trial | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 7 | |
| oaire.citation.startPage | e70308 | |
| oaire.citation.title | Journal of Cosmetic Dermatology | |
| oaire.citation.volume | 24 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |