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Citotoxicidade do bisfenol-A : revisão sistemática e meta-análise
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Advisor(s)
Abstract(s)
Objectivo: O objectivo desta revisão sistemática e meta-análise é avaliar, de forma
qualitativa e quantitativa, os resultados dos vários estudos realizados em modelo
murino, que analisam os efeitos citotóxicos do composto Bisfenol-A (BPA) e as suas
possíveis implicações no sistema reprodutivo e fertilidade.
Métodos: A pesquisa sistemática foi realizada a partir de duas bases de dados
universais electrónicas, PubMed/Medline e Google Scholar. Os resultados dos artigos
selecionados nesta revisão foram convertidos em magnitudes de dose-efeito através do
software dosresmeta, a correr em Rstudio e posteriormente exibidos na forma de
gráficos de regressão dose-efeito. As magnitudes de dose-efeito foram posteriormente
agrupadas de acordo com o tipo de tratamento, para o ajuste de uma meta-análise de
sub-grupos com efeitos randomizados através do software OpenMeta[Analyst].
Resultados: Relativamente à administração intragástrica de BPA em diferentes formas
(tratamento), foi observada uma diminuição substancial do número de fêmeas grávidas e
do número de fetos viáveis, tanto nos ensaios com fêmeas tratadas, como nos ensaios
com machos tratados. Por outro lado, a administração oral de BPA e Bis-GMA às
fêmeas não teve efeito significativo no seu risco relativo de infertilidade.
Conclusão: O BPA, nas suas diversas formas, parece ter um efeito negativo na
fertilidade murina quando absorvido diretamente no estômago. No entanto é necessário
ter em conta que as dosagens administradas aos ratos, nos estudos incluídos nesta
revisão, podem ser consideradas relativamente elevadas quando comparadas com as
quantidades libertadas dos materiais dentários em boca. Assim, não é claro se o BPA
afecta a fertilidade humana, no entanto, tendo em conta a literatura, é pertinente o
desenvolvimento de materiais dentários com substitutos para este composto, de modo a
este ser retirado das suas formulações.
Objective: The objective of this systematic review and meta-analysis is to evaluate, in a qualitative and quantitative way, the results of the various studies carried out in a murine model, which analyze the cytotoxic effects of the compound Bisphenol-A and its possible implications in the reproductive system and fertility. Methods: The systematic search was carried out from two universal databases, PubMed/Medline and Google Scholar. The results of the articles selected in this review were converted into dose-effect magnitudes using the dossmeta software, running in Rstudio and subsequently displayed in the form of dose-effect regression graphs. The dose-effect magnitudes were later grouped according to the type of treatment, for the adjustment of a meta-analysis of subgroups with randomized effects using the OpenMeta [Analyst] software. Results: Regarding the intragastric administration of Bisphenol-A in different forms, a substantial decrease in the number of pregnant females and the number of viable fetuses was observed, both in the tests with treated females and in the tests with treated males. On the other hand, oral administration of Bisphenol-A and Bis-GMA to females had no significant effect on their relative risk of infertility. Conclusion: BPA, in its various forms, appears to have a negative effect on murine fertility when absorbed directly into the stomach. However it is necessary to bear in mind that the dosages administered to rats, in the studies included in the review, can be considered relatively high when compared to the amounts released from dental materials in the oral cavity. Thus, it is not conclusive whether BPA affects human fertility, however, taking into account the literature, it is pertinent to manufacture dental materials with substitutes for this compound, so that it can be removed from its formulation.
Objective: The objective of this systematic review and meta-analysis is to evaluate, in a qualitative and quantitative way, the results of the various studies carried out in a murine model, which analyze the cytotoxic effects of the compound Bisphenol-A and its possible implications in the reproductive system and fertility. Methods: The systematic search was carried out from two universal databases, PubMed/Medline and Google Scholar. The results of the articles selected in this review were converted into dose-effect magnitudes using the dossmeta software, running in Rstudio and subsequently displayed in the form of dose-effect regression graphs. The dose-effect magnitudes were later grouped according to the type of treatment, for the adjustment of a meta-analysis of subgroups with randomized effects using the OpenMeta [Analyst] software. Results: Regarding the intragastric administration of Bisphenol-A in different forms, a substantial decrease in the number of pregnant females and the number of viable fetuses was observed, both in the tests with treated females and in the tests with treated males. On the other hand, oral administration of Bisphenol-A and Bis-GMA to females had no significant effect on their relative risk of infertility. Conclusion: BPA, in its various forms, appears to have a negative effect on murine fertility when absorbed directly into the stomach. However it is necessary to bear in mind that the dosages administered to rats, in the studies included in the review, can be considered relatively high when compared to the amounts released from dental materials in the oral cavity. Thus, it is not conclusive whether BPA affects human fertility, however, taking into account the literature, it is pertinent to manufacture dental materials with substitutes for this compound, so that it can be removed from its formulation.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Bisfenol-A Fertilidade Bis-GMA Ratos