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Periodontal inflammation is associated with increased circulating levels of endothelial progenitor cells : a retrospective cohort study in a high vascular risk population

2023-06Contributo em revista Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorVázquez-Reza, María
dc.contributor.authorCustodia, Antía
dc.contributor.authorLópez-Dequidt, Iria
dc.contributor.authorAramburu-Núñez, Marta
dc.contributor.authorRomaus-Sanjurjo, Daniel
dc.contributor.authorOuro, Alberto
dc.contributor.authorBotelho, João
dc.contributor.authorMachado, Vanessa
dc.contributor.authorIglesias-Rey, Ramón
dc.contributor.authorPías-Peleteiro, Juan Manuel
dc.contributor.authorLeira, Rogelio
dc.contributor.authorBlanco, Juan
dc.contributor.authorCastillo, José
dc.contributor.authorSobrino, Tomás
dc.contributor.authorLeira, Yago
dc.date.accessioned2026-03-09T15:36:38Z
dc.date.available2026-03-09T15:36:38Z
dc.date.issued2023-06
dc.description.abstractBackground: One of the main biological mechanisms behind the link between periodontitis and atherosclerotic vascular diseases is vascular endothelial dysfunction. Particularly, circulating endothelial progenitor cells (EPCs) have been considered a biomarker of altered vascular endothelial function. Objectives: The aim of this study was to investigate relationship between periodontal inflammation and increased number of circulating EPCs. Design: This is retrospective cohort study. Methods: In this study, 85 elderly patients with a previous history of hypertension were followed up to 12 months. A baseline full-mouth periodontal assessment was carried out, and the amount of periodontal tissue inflamed per subject was calculated as a proxy of periodontal inflammation [periodontal inflamed surface area (PISA)]. The number of circulating EPCs (CD34+/CD133+/KDR+) was determined by flow cytometry from peripheral blood samples collected at baseline and 12 months. Results: Mean concentrations of CD34+/CD133+/KDR+ progenitor cells were higher in periodontitis patients than in those without periodontitis at baseline [55.4, 95% confidence interval (CI) = 20.8 to 90.0 versus 27.2, 95% CI = 13.6 to 40.8, p = 0.008] and 12 months (114.6, 95% CI = 53.5 to 175.7 versus 19.1, 95% CI = 10.8 to 27.4, p = 0.003). A significant increase over the follow-up was noticed in the group of subjects with periodontitis (p = 0.049) but not in the nonperiodontitis group (p = 0.819). PISA was independently associated with CD34+/CD133+/KDR+ EPCs at baseline (B coefficient = 0.031, 95% CI = 0.005 to 0.058; p = 0.021). The relationship between PISA and CD34+/CD133+/KDR+ EPCs at 12 months was confounded by increased baseline body mass index (B coefficient = 0.064, 95% CI = −0.005 to 0.132; p = 0.066). Conclusion: Periodontal inflammation is associated with high number of CD34+/CD133+/KDR+ EPCs, thus supporting a potential link between periodontitis and endothelial dysfunction.eng
dc.identifier.citationVázquez-Reza, M., Custodia, A., López-Dequidt, I., Aramburu-Núñez, M., Romaus-Sanjurjo, D., Ouro, A., Botelho, J., Machado, V., Iglesias-Rey, R., Pías-Peleteiro, J. M., Leira, R., Blanco, J., Castillo, J., Sobrino, T., & Leira, Y. (2023). Periodontal inflammation is associated with increased circulating levels of endothelial progenitor cells: a retrospective cohort study in a high vascular risk population. Therapeutic advances in chronic disease, 14, 20406223231178276. https://doi.org/10.1177/20406223231178276
dc.identifier.doi10.1177/20406223231178276
dc.identifier.issn2978-1558
dc.identifier.urihttp://hdl.handle.net/10400.26/62066
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSage
dc.relation.hasversionhttps://doi.org/10.1177/20406223231178276
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectbiomarker
dc.subjectendothelial function
dc.subjectendothelial progenitor cells
dc.subjectinflammation
dc.subjectperiodontitis
dc.titlePeriodontal inflammation is associated with increased circulating levels of endothelial progenitor cells : a retrospective cohort study in a high vascular risk populationeng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.titleSage Open Chronic Disease
oaire.citation.volume14
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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