Structure and function of human matrix metalloproteinases

Laronha, Helena; Caldeira, Jorge

http://hdl.handle.net/10400.26/58300

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Authors

Laronha, Helena

Caldeira, Jorge

Abstract(s)

The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenance of collagen, and consequently of ECM, is involved in several biological processes and it must be strictly regulated by endogenous inhibitors (TIMPs). The deregulation of MMPs activity leads to development of numerous diseases. This review shows MMPs complexity.

Keywords

matrix metalloproteinases TIMP collagen

URI

http://hdl.handle.net/10400.26/58300

Citation

Laronha, H., & Caldeira, J. (2020). Structure and Function of Human Matrix Metalloproteinases. Cells, 9(5), 1076. https://doi.org/10.3390/cells9051076