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Publication
Relação entre o microbioma bacteriano gastrointestinal com a doença inflamatória intestinal e o linfoma em cães e gatos
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Advisor(s)
Abstract(s)
O microbioma gastrointestinal caracteriza-se como o conjunto de microrganismos que habitam
o trato gastrointestinal, sendo considerado um componente integral do sistema digestivo. Apesar da
sua constituição ser composta por bactérias, fungos, protozoários e vírus, a presente dissertação
aborda apenas a componente bacteriana, pela representatividade e pelos benefícios que oferecem ao
hospedeiro. Nos cães e gatos saudáveis, os filos predominantes são Fusobacteria, Bacterioidetes,
Firmicutes, Proteobacteria e Actinobacteria. O microbioma canino e felino tem uma constituição
semelhante, apesar da possibilidade de variação interindividual devido a numerosos fatores tanto
endógenos como exógenos. A saúde dos animais de companhia está interligada com a sua composição
microbiana, a qual se encontra alterada em diferentes doenças gastrointestinais, tais como em linfoma
e doença inflamatória intestinal (IBD). Nestas enteropatias ocorre uma alteração da composição
microbiana, sendo que o seu estudo é essencial para que no futuro seja possível utilizar esta
informação na modulação do tratamento, adaptado às alterações características de cada doença ou
indivíduo tal como na determinação do prognóstico.
Na presente dissertação, pretende-se efetuar uma revisão, de forma sumária, sobre o microbioma
bacteriano em cães e gatos, relativamente ao conhecimento atual sobre composição e funções, bem
como as principais técnicas de avaliação. A influência e alterações do microbioma na doença
gastrointestinal, em particular na doença inflamatória intestinal e no linfoma alimentar serão
adicionalmente abordados.
The gastrointestinal microbiome is characterized as the group of microorganisms that inhabit the gastrointestinal system, being considered an essential component of the gastrointestinal system. Despite being composed of bacteria, fungus, protozoa and viruses, the present dissertation focuses on the bacterial component. In healthy animals, the predominant phyla are Fusobacteria, Bacterioidetes, Firmicutes, Proteobacteria e Actinobacteria. The canine and feline microbiome have a similar constitution, although it can differ between individuals due to a number of endogenous and exogenous factors. Companion animal health is interconnected with the microbiome composition. In fact, the composition is altered in different gastrointestinal diseases such as lymphoma and inflammatory bowel disease (IBD). In these enteropathies occurs a change in the microbiome composition. The study of these alterations is essential so that this information can be used in the future for modulation of treatment, adapted to characteristic changes of each disease, and in determining the prognosis. In the present dissertation, a summarized review is made on the bacterial component of the microbiome in cats and dogs, relatively to the knowledge there is today about its composition and functions as well as the methods used to evaluate these parameters. The influence and alterations of the microbiome in gastrointestinal disease, in particular in inflammatory bowel disease and in alimentary lymphoma will be additionally approached.
The gastrointestinal microbiome is characterized as the group of microorganisms that inhabit the gastrointestinal system, being considered an essential component of the gastrointestinal system. Despite being composed of bacteria, fungus, protozoa and viruses, the present dissertation focuses on the bacterial component. In healthy animals, the predominant phyla are Fusobacteria, Bacterioidetes, Firmicutes, Proteobacteria e Actinobacteria. The canine and feline microbiome have a similar constitution, although it can differ between individuals due to a number of endogenous and exogenous factors. Companion animal health is interconnected with the microbiome composition. In fact, the composition is altered in different gastrointestinal diseases such as lymphoma and inflammatory bowel disease (IBD). In these enteropathies occurs a change in the microbiome composition. The study of these alterations is essential so that this information can be used in the future for modulation of treatment, adapted to characteristic changes of each disease, and in determining the prognosis. In the present dissertation, a summarized review is made on the bacterial component of the microbiome in cats and dogs, relatively to the knowledge there is today about its composition and functions as well as the methods used to evaluate these parameters. The influence and alterations of the microbiome in gastrointestinal disease, in particular in inflammatory bowel disease and in alimentary lymphoma will be additionally approached.
Description
Keywords
Bactérias IBD Linfoma Microbioma gastrointestinal Bacteria Gastrointestinal microbiome Lymphoma