Publicação
Vitamin D and periodontitis: a systematic review and meta-analysis
| datacite.subject.fos | Ciências Médicas | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Machado, Vanessa | |
| dc.contributor.author | Lobo, Sofia | |
| dc.contributor.author | Proença, Luís | |
| dc.contributor.author | Mendes, José João | |
| dc.contributor.author | Botelho, João | |
| dc.date.accessioned | 2025-09-05T11:32:27Z | |
| dc.date.available | 2025-09-05T11:32:27Z | |
| dc.date.issued | 2020-08 | |
| dc.description.abstract | To explore the vitamin D levels of periodontitis patients in comparison with periodontally healthy ones, and to assess the influence of vitamin D supplementation as an adjunctive during nonsurgical periodontal treatment (NSPT). Five databases (Pubmed, Embase, Scholar, Web of Sciences, and Cochrane Library) were searched until May 2020. Mean difference (MD) meta-analysis with corresponding 95% confidence interval (95% CI) and sensitivity tests via meta-regression were used. We followed Strength of Recommendation Taxonomy (SORT) to appraise the strength and quality of the evidence. Sixteen articles were included, fourteen case-control and two intervention studies, all reporting 25-hydroxyvitamin D (25(OH)D) levels. Compared with the healthy controls, the circulating 25(OH)D levels were significantly lower in chronic periodontitis patients (pooled MD = −6.80, 95% CI: −10.59 to −3.02). Subgroup analysis revealed differences among 25(OH)D measurements, with liquid chromatography-mass spectrometry being the most homogeneous method (pooled MD = −2.05, 95% CI: −3.40 to −0.71). Salivary levels of 25(OH)D showed no differences between groups. Due to the low number of studies, conclusions on aggressive periodontitis and in the effect of vitamin D supplementation after NSPT were not possible to ascribe. Compared with healthy controls, 25(OH)D serum levels are significantly lower in chronic periodontitis patients, with an overall SORT A recommendation. Future studies are needed to clarify the effect of vitamin D supplementation and the biological mechanisms linking vitamin D to the periodontium. | eng |
| dc.identifier.citation | Machado V, Lobo S, Proença L, Mendes JJ, Botelho J. Vitamin D and Periodontitis: A Systematic Review and Meta-Analysis. Nutrients. 2020; 12(8):2177. https://doi.org/10.3390/nu12082177 | |
| dc.identifier.doi | 10.3390/nu12082177 | |
| dc.identifier.issn | 2072-6643 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/58586 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation.hasversion | https://doi.org/10.3390/nu12082177 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | vitamin D | |
| dc.subject | vitamin D deficiency | |
| dc.subject | 25(OH)D | |
| dc.subject | periodontal disease | |
| dc.subject | periodontitis | |
| dc.subject | systematic review | |
| dc.subject | meta-analysis | |
| dc.title | Vitamin D and periodontitis: a systematic review and meta-analysis | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 8 | |
| oaire.citation.startPage | 2177 | |
| oaire.citation.title | Nutrients | |
| oaire.citation.volume | 12 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |