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Development and optimization of a new method to determine antidepressants in oral fluid by microextraction by packed sorbent and analysis by GC-MS/MS

2022-12Conference object Open access
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dc.contributor.authorSoares, Sofia
dc.contributor.authorRosado, Tiago
dc.contributor.authorBarroso, Mário
dc.contributor.authorGallardo, Eugenia
dc.date.accessioned2023-03-13T15:49:03Z
dc.date.available2023-03-13T15:49:03Z
dc.date.issued2022-12
dc.descriptionPoster apresentado no 12º Encontro Nacional de Cromatografia, Aveiro, Dezembro de 2022pt_PT
dc.description.abstractBetween 2013 and 2016, the consumption of antidepressants doubled in Portugal, with around 30 million packages of medication for depression, anxiety and other mental health problems dispensed annually. This phenomenon has even given rise to several alerts, which was highlighted in the 2017 report of the National Program for Mental Health, as Portugal has one of the highest rates of mental illness in Europe1. Therapeutic drug monitoring is well established for a small number of drugs, namely for those where a direct relationship between concentration and pharmacological effect at the site of action exists, which in turn is predictably reflected in the response. Drug concentrations in the various biological fluids are used in conjunction with other clinical observation measures to assess the patient's condition, and further support the individualization of therapy. Within this group of drugs targeted for monitoring are antidepressants. In recent years, oral fluid has gained more and more importance in the field of therapeutic drug monitoring, as a non-invasive and painless alternative to traditionally sampled specimens (e.g. blood, plasma). MEPS is a miniaturized solid-phase extraction (SPE) and therefore has a great advantage in the reduced operating volumes and consequently lower amounts of sample and organic solvents are required. As a result, MEPS decreases the time required for extraction, clean-up and concentration of analytes. This is the first work that uses MEPS as sample preparation technique for the determination of antidepressants and metabolites in oral fluid samples (250 µL). The simple extraction procedure proved to be efficient, requiring only 250 µL of biological sample, making it an excellent alternative for the determination of these compounds in routine clinical and forensic toxicology laboratories and for therapeutic monitoring purposes.pt_PT
dc.description.sponsorshipPOCI-01-0145-FEDER-007491
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/44100
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationHealth Sciences Research Centre
dc.relationHealth Sciences Research Centre
dc.relationThe potential use of oral fluid to monitor antidepressants in clinical and forensic scenarios
dc.subjectAntidepressantspt_PT
dc.subjectOral fluidpt_PT
dc.subjectMEPSpt_PT
dc.titleDevelopment and optimization of a new method to determine antidepressants in oral fluid by microextraction by packed sorbent and analysis by GC-MS/MSpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleThe potential use of oral fluid to monitor antidepressants in clinical and forensic scenarios
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F148753%2F2019/PT
oaire.citation.conferencePlaceAveiropt_PT
oaire.citation.title12º Encontro Nacional de Cromatografiapt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSoares
person.familyNameRosado
person.familyNameBarroso
person.familyNameGallardo
person.givenNameSofia
person.givenNameTiago
person.givenNameMário
person.givenNameEugenia
person.identifier.ciencia-id0214-8794-861B
person.identifier.ciencia-idC21B-DCC7-1C44
person.identifier.ciencia-id5110-F476-ECCC
person.identifier.ciencia-idF617-5CA5-EF61
person.identifier.orcid0000-0002-3524-5791
person.identifier.orcid0000-0003-0469-2895
person.identifier.orcid0000-0001-8848-2734
person.identifier.orcid0000-0002-1802-8998
person.identifier.scopus-author-id57204097945
person.identifier.scopus-author-id35329243100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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