Noise rich in low frequency components, a new comorbidity for periodontal disease? An experimental study

Mendes, José João; Oliveira, Pedro Miguel Antunes; Brito, José; Águas, Artur Manuel Perez Neves; Martins dos Santos, José António Mesquita

http://hdl.handle.net/10400.26/8170

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Authors

Mendes, José João

Oliveira, Pedro Miguel Antunes

Brito, José

Águas, Artur Manuel Perez Neves

Martins dos Santos, José António Mesquita

Abstract(s)

"Introduction: Exposure to noise rich in low frequency components induces abnormal proliferation of extracellular matrix and collagens. The previous studies have shown alterations in the periodontium of both humans and animals. Our objective was the evaluation of collagens I, IV and V of the periodontium of Wistar rats exposed to noise rich in low frequency components. Materials and Methods: 5 groups (each with 10 animals) were exposed to continuous low frequency noise (LFN). The LFN, from previously recorded white noise, frequency filtered and amplified, was applied in growing periods of 1, 3, 5, 9 and 13 weeks, in order to characterize the alterations with exposure time. A control group of ten animals was kept in silence. These animals were used in groups of 2 as aged‑matched controls. After exposure, sections were obtained including teeth, alveolar bone and periodontium and observed after immunollabeling for collagens I, IV and V. Results: A significant increase in collagen I was observed in exposed groups (P < 0.001) (Kruskal‑Wallis test). Post‑hoc comparisons (Mann‑Whitney test with Bonferroni correction) showed an increase in collagen I in animals exposed for 3 weeks or more (P < 0.001). The same test was applied to collagen V where significant differences were found when comparing control and exposed groups (P ≤ 0.004). The t‑test for independent samples was applied to collagen type IV where no significant differences were found (P = 0.410), when comparing to the control group. Discussion: As in other organs, we can observe fibrosis and the newly formed collagen is likely to be “nonfunctional,” which could have clinical impact. Conclusion: Noise may constitute a new comorbidity for periodontal disease."

Description

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

Fibrosis Low frequency noise Periodontal disease Periodontium

URI

http://hdl.handle.net/10400.26/8170

Citation

Baltazar Mendes JJ, Oliveira PA, Brito J, Neves Águas AP, Martins dos Santos JM. Noise rich in low frequency components, a new comorbidity for periodontal disease? An experimental study. J Indian Soc Periodontol 2014;18:503-7.