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Tracing the impact of public health interventions on HIV-1 transmission in Portugal using molecular epidemiology

2019-07Contribution to journal Open access
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorVasylyeva, Tetyana I.
dc.contributor.authorPlessis, Louis du
dc.contributor.authorPineda-Peña, Andrea C.
dc.contributor.authorKühnert, Denise
dc.contributor.authorLemey, Philippe
dc.contributor.authorVandamme, Anne-Mieke
dc.contributor.authorGomes, Perpétua
dc.contributor.authorCamacho, Ricardo J.
dc.contributor.authorPybus, Oliver G.
dc.contributor.authorAbecasis, Ana B.
dc.contributor.authorFaria, Nuno R.
dc.date.accessioned2025-07-17T14:36:57Z
dc.date.available2025-07-17T14:36:57Z
dc.date.issued2019-07
dc.description.abstractBackground Estimation of temporal changes in human immunodeficiency virus (HIV) transmission patterns can help to elucidate the impact of preventive strategies and public health policies. Methods Portuguese HIV-1 subtype B and G pol genetic sequences were appended to global reference data sets to identify country-specific transmission clades. Bayesian birth-death models were used to estimate subtype-specific effective reproductive numbers (Re). Discrete trait analysis (DTA) was used to quantify mixing among transmission groups. Results We identified 5 subtype B Portuguese clades (26–79 sequences) and a large monophyletic subtype G Portuguese clade (236 sequences). We estimated that major shifts in HIV-1 transmission occurred around 1999 (95% Bayesian credible interval [BCI], 1998–2000) and 2000 (95% BCI, 1998–2001) for subtypes B and G, respectively. For subtype B, Re dropped from 1.91 (95% BCI, 1.73–2.09) to 0.62 (95% BCI,.52–.72). For subtype G, Re decreased from 1.49 (95% BCI, 1.39–1.59) to 0.72 (95% BCI, .63–.8). The DTA suggests that people who inject drugs (PWID) and heterosexuals were the source of most (>80%) virus lineage transitions for subtypes G and B, respectively. Conclusions The estimated declines in Re coincide with the introduction of highly active antiretroviral therapy and the scale-up of harm reduction for PWID. Inferred transmission events across transmission groups emphasize the importance of prevention efforts for bridging populations.eng
dc.identifier.citationTetyana I Vasylyeva, Louis du Plessis, Andrea C Pineda-Peña, Denise Kühnert, Philippe Lemey, Anne-Mieke Vandamme, Perpétua Gomes, Ricardo J Camacho, Oliver G Pybus, Ana B Abecasis, Nuno R Faria, Tracing the Impact of Public Health Interventions on HIV-1 Transmission in Portugal Using Molecular Epidemiology, The Journal of Infectious Diseases, Volume 220, Issue 2, 15 July 2019, Pages 233–243, https://doi.org/10.1093/infdis/jiz085
dc.identifier.doi10.1093/infdis/jiz085
dc.identifier.issn1537-6613
dc.identifier.urihttp://hdl.handle.net/10400.26/58099
dc.language.isoeng
dc.peerreviewedyes
dc.publisherOxford University Press
dc.relation.hasversionhttps://doi.org/10.1093/infdis/jiz085
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHIV
dc.subjectPortugal
dc.subjectphylodynamics
dc.subjectepidemiology
dc.subjectreproductive number
dc.subjecttransmission groups
dc.subjectharm reduction
dc.titleTracing the impact of public health interventions on HIV-1 transmission in Portugal using molecular epidemiologyeng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.endPage243
oaire.citation.issue2
oaire.citation.startPage233
oaire.citation.titleJournal of Infectious Diseases
oaire.citation.volume220
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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