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European consensus on malabsorption—UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN. Part 1 : definitions, clinical phenotypes, and diagnostic testing for malabsorption

2025-05Contributo em revista Acesso aberto
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorLenti, Marco Vincenzo
dc.contributor.authorHammer, Heinz Florian
dc.contributor.authorTacheci, Ilja
dc.contributor.authorBurgos, Rosa
dc.contributor.authorSchneider, Stephane
dc.contributor.authorFoteini, Anastasiou
dc.contributor.authorDerovs, Aleksejs
dc.contributor.authorKeller, Jutta
dc.contributor.authorBroekaert, Ilse
dc.contributor.authorArvanitakis, Marianna
dc.contributor.authorDumitrascu, Dan Lucian
dc.contributor.authorSegarra-Cantón, Oscar
dc.contributor.authorKrznarić, Željko
dc.contributor.authorPokrotnieks, Juris
dc.contributor.authorNunes, Gonçalo
dc.contributor.authorHammer, Johann
dc.contributor.authorPironi, Loris
dc.contributor.authorSonyi, Marc
dc.contributor.authorSabo, Cristina Maria
dc.contributor.authorMendive, Juan
dc.contributor.authorNicolau, Adrien
dc.contributor.authorDolinsek, Jernej
dc.contributor.authorKyselova, Denisa
dc.contributor.authorLaterza, Lucrezia
dc.contributor.authorGasbarrini, Antonio
dc.contributor.authorSurdea-Blaga, Teodora
dc.contributor.authorFonseca, Jorge
dc.contributor.authorLionis, Christos
dc.contributor.authorCorazza, Gino Roberto
dc.contributor.authorSabatino, Antonio Di
dc.date.accessioned2026-05-07T11:26:12Z
dc.date.available2026-05-07T11:26:12Z
dc.date.issued2025-05
dc.description.abstractMalabsorption is a complex and multifaceted condition characterised by the defective passage of nutrients into the blood and lymphatic streams. Several congenital or acquired disorders may cause either selective or global malabsorption in both children and adults, such as cystic fibrosis, exocrine pancreatic insufficiency (EPI), coeliac disease (CD) and other enteropathies, lactase deficiency, small intestinal bacterial overgrowth (SIBO), autoimmune atrophic gastritis, Crohn's disease, and gastric or small bowel resections. Early recognition of malabsorption is key for tailoring a proper diagnostic work-up for identifying the cause of malabsorption. A patient's medical and pharmacological history is essential for identifying risk factors. Several examinations such as endoscopy with small intestinal biopsies, non-invasive functional tests and radiological imaging are useful in diagnosing malabsorption. Because of its high prevalence, CD should always be looked for in cases of malabsorption with no other obvious explanations and in high-risk individuals. Nutritional support is key in the management of patients with malabsorption; different options are available, including oral supplements, enteral or parenteral nutrition. In patients with short bowel syndrome, teduglutide proved effective in reducing the need for parenteral nutrition, thus improving the quality of life of these patients. Primary care physicians play a central role in the early detection of malabsorption and should be involved in multidisciplinary teams for improving the overall management of these patients. In this European consensus, involving ten scientific societies and several experts, we have dissected all the issues around malabsorption, including the definitions and diagnostic testing (Part 1), high-risk categories and special populations, nutritional assessment and management, and primary care perspective (Part 2).eng
dc.identifier.citationLenti, M.V., Hammer, H.F., Tacheci, I., Burgos, R., Schneider, S., Foteini, A., Derovs, A., Keller, J., Broekaert, I., Arvanitakis, M., Dumitrascu, D.L., Segarra-Cantón, O., Krznarić, Ž., Pokrotnieks, J., Nunes, G., Hammer, J., Pironi, L., Sonyi, M., Sabo, C.M., Mendive, J., Nicolau, A., Dolinsek, J., Kyselova, D., Laterza, L., Gasbarrini, A., Surdea-Blaga, T., Fonseca, J., Lionis, C., Corazza, G.R. and Di Sabatino, A. (2025), European Consensus on Malabsorption—UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN. Part 1: Definitions, Clinical Phenotypes, and Diagnostic Testing for Malabsorption. United European Gastroenterol J, 13: 599-613. https://doi.org/10.1002/ueg2.70012
dc.identifier.doi10.1002/ueg2.70012
dc.identifier.issn2050-6414
dc.identifier.urihttp://hdl.handle.net/10400.26/63022
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.relation.hasversionhttps://doi.org/10.1002/ueg2.70012
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectbreath test
dc.subjectcoeliac disease
dc.subjectdiarrhoea
dc.subjectenteropathy
dc.subjectnutrition
dc.subjectpancreatitis
dc.subjectweight loss
dc.titleEuropean consensus on malabsorption—UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN. Part 1 : definitions, clinical phenotypes, and diagnostic testing for malabsorptioneng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.endPage613
oaire.citation.issue4
oaire.citation.startPage599
oaire.citation.titleUnited European Gastroenterology Journal
oaire.citation.volume13
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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