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Publication
Aplicação clínica de células estaminais no tratamento de osteoartrite em cães
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Abstract(s)
A osteoartrite é a síndrome clínica mais comum de dor e disfunção nas articulações, acompanhado por diferentes graus de limitação funcional e diminuição da qualidade de vida. Esta patologia de carácter progressivo, também designada de doença articular degenerativa (DAD), artrose ou osteoartrose, é caracterizada por um grupo de anomalias mecânicas, alterações degenerativas da articulação e de estruturas adjacentes, com perda significativa dos seus componentes e uma remodelação anormal dos tecidos articulares.
As células estaminais são células indiferenciadas, ou seja, que não possuem uma especialização funcional, e que apresentam capacidade de gerar os diversos tipos celulares que constituem um organismo. São caracterizadas pela sua capacidade de proliferação, autorrenovação, produção de diferentes linhagens celulares e regeneração de tecidos. Entre estas estacam-se as células estaminais mesenquimatosas com origem no tecido adiposo, pela sua capacidade de regeneração de tecidos lesados e capacidade imunomoduladora que lhe atribuem interesse terapêutico.
A presente revisão tem como objetivo reunir informação de publicações que abordem a temática da utilização clínica de células estaminais em casos de osteoartrite em cães.
Osteoarthritis is the most common clinical syndrome of pain in the articulations and dysfunction, accompanied by different degrees of functional limitation, and reduced quality of life. This pathology, with progressive character, also called degenerative articulation disease (DAD), arthrosis or osteoarthrosis, it’s characterized by a group of mechanical anomalies, degenerative alterations of the articulation and adjacent structures, with significant loss of its components, and an abnormal remodeling of the articular tissues. Stem cells are defined as undifferentiated cells, in other words, they don't have a functional specialization and they have the ability to generate different cell types that form an organism. They are characterized for their proliferation ability, self-renovation, production of different cell lineages and tissue regeneration. Amongst these, the Mesenchymal Stem Cells, with origin on the adipose tissue, stand out, for their ability to regenerate injured tissues and immunomodulation, which gives them therapeutic appeal. The purpose of this work, is to gather information of publications that address the clinical use of stem cells in cases of osteoarthritis in dogs.
Osteoarthritis is the most common clinical syndrome of pain in the articulations and dysfunction, accompanied by different degrees of functional limitation, and reduced quality of life. This pathology, with progressive character, also called degenerative articulation disease (DAD), arthrosis or osteoarthrosis, it’s characterized by a group of mechanical anomalies, degenerative alterations of the articulation and adjacent structures, with significant loss of its components, and an abnormal remodeling of the articular tissues. Stem cells are defined as undifferentiated cells, in other words, they don't have a functional specialization and they have the ability to generate different cell types that form an organism. They are characterized for their proliferation ability, self-renovation, production of different cell lineages and tissue regeneration. Amongst these, the Mesenchymal Stem Cells, with origin on the adipose tissue, stand out, for their ability to regenerate injured tissues and immunomodulation, which gives them therapeutic appeal. The purpose of this work, is to gather information of publications that address the clinical use of stem cells in cases of osteoarthritis in dogs.
Description
Keywords
Osteoartrite Terapia celular Células estaminais derivadas do tecido adiposo Cães Osteoarthritis Cell therapy Stem cells derived from adipose tissue Dogs