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Assessing of depth of myometrial invasion and preoperative staging of endometrial cancer: the added value of diffusion-weighted imaging and dynamic contrast-enhanced MRI sequences

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dc.contributor.authorAlves, Inês
dc.contributor.authorRamalho, Madalena
dc.contributor.authorCunha, Teresa Margarida
dc.date.accessioned2017-04-04T14:17:29Z
dc.date.available2017-04-04T14:17:29Z
dc.date.issued2017
dc.date.updated2017-03-19T15:25:43Z
dc.description.abstractPurpose: To compare T2-weighted image (T2WI) vs dynamic contrastenhanced magnetic resonance imaging (DCE-MRI) vs diffusion-weighted imaging (DWI) for the evaluation of depth of myometrial invasion and preoperative overall staging of endometrial cancer. Methods and Materials: This retrospective study included forty-four women with endometrial cancer who underwent 1.5 Tesla pelvic MRI as part of their initial preoperative staging. T2WI, DCE-MRI, and DWI sequences were obtained. Retrospectively, two radiologists performed a consensus interpretation of all images interpreted the depth of myometrial invasion, overall stage, and presence of pitfalls. Surgical histology was available for each case and was the gold standard for comparison. The accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for each method were assessed. Results: Respective diagnostic accuracy, sensitivity, specificity, PPV and NPV in assessing the depth of myometrial invasion were: T2WI 61%, 58%, 64%, 55% and 67%; DCE-MRI 86%, 84%, 88%, 84% and 88%; DWI 95%, 95%, 96%, 95% and 96%. DWI correctly staged more patients (41/44) than DCEMRI (34/44) and T2WI (22/44) (P<0.05). For overall cancer staging, κ values were 0.29 with T2WI, 0.59 with DCE-MRI, and 0.89 with DWI. Conclusion: DWI considerably improved the diagnostic sensitivity and accuracy of MRI compared to DCE-MRI and T2WI in assessing both depth of myometrial invasion and overall staging in endometrial cancer.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier1869-4101en_US
dc.identifier.citationInês Alves; Madalena Ramalho; Teresa Margarida Cunha. Assessing of depth of myometrial invasion and preoperative staging of endometrial cancer: the added value of diffusion-weighted imaging and dynamic contrast-enhanced MRI sequences, Trabalho apresentado em ECR 2017 – European Congress of Radiology, In Insights Imaging , Vienna, 2017.pt_PT
dc.identifier.doi10.1007/s13244-017-0546-5pt_PT
dc.identifier.issn1869-4101
dc.identifier.urihttp://hdl.handle.net/10400.26/18160
dc.language.isoengpt_PT
dc.publisherSpringer Berlin Heidelbergpt_PT
dc.titleAssessing of depth of myometrial invasion and preoperative staging of endometrial cancer: the added value of diffusion-weighted imaging and dynamic contrast-enhanced MRI sequencespt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.titleInsights into Imagingpt_PT
oaire.citation.volume8pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typebookPartpt_PT

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