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Advisor(s)
Abstract(s)
Purpose: To compare T2-weighted image (T2WI) vs dynamic contrastenhanced
magnetic resonance imaging (DCE-MRI) vs diffusion-weighted
imaging (DWI) for the evaluation of depth of myometrial invasion and
preoperative overall staging of endometrial cancer.
Methods and Materials: This retrospective study included forty-four women
with endometrial cancer who underwent 1.5 Tesla pelvic MRI as part of their
initial preoperative staging. T2WI, DCE-MRI, and DWI sequences were
obtained. Retrospectively, two radiologists performed a consensus
interpretation of all images interpreted the depth of myometrial invasion, overall
stage, and presence of pitfalls. Surgical histology was available for each case
and was the gold standard for comparison. The accuracy, sensitivity,
specificity, positive predictive value (PPV) and negative predictive value (NPV)
for each method were assessed.
Results: Respective diagnostic accuracy, sensitivity, specificity, PPV and NPV
in assessing the depth of myometrial invasion were: T2WI 61%, 58%, 64%,
55% and 67%; DCE-MRI 86%, 84%, 88%, 84% and 88%; DWI 95%, 95%,
96%, 95% and 96%. DWI correctly staged more patients (41/44) than DCEMRI
(34/44) and T2WI (22/44) (P<0.05). For overall cancer staging, κ values
were 0.29 with T2WI, 0.59 with DCE-MRI, and 0.89 with DWI.
Conclusion: DWI considerably improved the diagnostic sensitivity and
accuracy of MRI compared to DCE-MRI and T2WI in assessing both depth of
myometrial invasion and overall staging in endometrial cancer.
Description
Keywords
Citation
Inês Alves; Madalena Ramalho; Teresa Margarida Cunha. Assessing of depth of myometrial invasion and preoperative staging of endometrial cancer: the added value of diffusion-weighted imaging and dynamic contrast-enhanced MRI sequences, Trabalho apresentado em ECR 2017 – European Congress of Radiology, In Insights Imaging , Vienna, 2017.
Publisher
Springer Berlin Heidelberg