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Publication
Associação dos polimorfismos dos genes da il-1 e do il-1ra com a peri-implatite
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Advisor(s)
Abstract(s)
A peri-implantite consiste numa condição patológica que ocorre nos tecidos em redor dos implantes, sendo caracterizada por inflamação na mucosa peri-implantar e subsequente perda progressiva de osso de suporte, devido à acumulação microbiana e/ ou fatores iatrogénicos. Contudo, a doença é provavelmente o resultado de vários fatores que podem influenciar a resposta inflamatória do hospedeiro, como o tabaco, o stress e variações genéticas, polimorfismos, em determinados genes relevantes para a reação imunológica.
Os principais objetivos desta revisão narrativa são caracterizar a peri-implantite, descrevendo a sua etiologia, os seus principais fatores de risco, prevalência, parâmetros de diagnóstico e principais formas de tratamento atuais. Também se pretende reunir a mais recente evidência científica acerca da possível relação entre a existência de polimorfismos nos genes IL-1A, IL-1β e IL-1RN e o desenvolvimento da peri-implantite. Também serão identificadas e descritas as principais técnicas laboratoriais genéticas e bioquímicas utilizadas para averiguar esta possível relação.
Para a realização desta revisão narrativa, foi efetuada uma pesquisa bibliográfica recorrendo às plataformas informáticas de literatura científica Pub-Med, SciELO, Medline e Cochrane. A pesquisa foi efetuada em Português e Inglês, recorrendo a termos chave como: “Peri-implantite/Peri-implantitis”, “diagnóstico peri-implantite/ Peri implantitis diagnostic” “tratamento peri-implantite /treatment”, “polimorfismos IL-1/ Il-1 Gene polymorphisms”, “Marcadores enzimáticos Peri-implantite/Peri-implantitis Biomarkers”.
Peri-implantitis consists in a pathologic condition that occurs in tissues surrounding the implants, characterized by inflammation in the peri-implant mucosa and subsequent progressive bone loss, caused by microbial accumulation and/or iatrogenic factors. However, the disease is likely to be the result of several factors that can influence the inflammatory host response, such as tobacco, stress and genetic variations, polymorphisms, in specific genes which are relevant for the immune response. The main objectives of this narrative review are to caracterize peri-implantitis, describing its etiology, main risk factors, prevalence, diagnostic parameters and its current main treatment pathways. It is also intended the gathering the most recent scientific evidence regarding the possible relation between the existence of IL-1A, IL-1β and IL-1RN gene polymorphisms and the development of peri-implantitis. The main genetic and biochemical laboratorial techniques used to verify this relation will also be identified and described. To develop this narrative review, a bibliographic search was conducted by resorting to the scientific literature computer platforms Pub-Med, SciELO, Medline and Cochraine, in order to scientifically support this work. The search was conducted in portuguese and english, by using keywords such as: “Peri-implantite/Peri-implantitis”, “diagnóstico peri-implantite/ Peri-implantitis diagnostic” “tratamento Peri-implantite/ Peri implantitistreatment”, “polimorfismos IL-1/ Il-1 Gene polymorphisms”, “Marcadores enzimáticos Peri-implantite/Peri-implantitis Biomarkers”.
Peri-implantitis consists in a pathologic condition that occurs in tissues surrounding the implants, characterized by inflammation in the peri-implant mucosa and subsequent progressive bone loss, caused by microbial accumulation and/or iatrogenic factors. However, the disease is likely to be the result of several factors that can influence the inflammatory host response, such as tobacco, stress and genetic variations, polymorphisms, in specific genes which are relevant for the immune response. The main objectives of this narrative review are to caracterize peri-implantitis, describing its etiology, main risk factors, prevalence, diagnostic parameters and its current main treatment pathways. It is also intended the gathering the most recent scientific evidence regarding the possible relation between the existence of IL-1A, IL-1β and IL-1RN gene polymorphisms and the development of peri-implantitis. The main genetic and biochemical laboratorial techniques used to verify this relation will also be identified and described. To develop this narrative review, a bibliographic search was conducted by resorting to the scientific literature computer platforms Pub-Med, SciELO, Medline and Cochraine, in order to scientifically support this work. The search was conducted in portuguese and english, by using keywords such as: “Peri-implantite/Peri-implantitis”, “diagnóstico peri-implantite/ Peri-implantitis diagnostic” “tratamento Peri-implantite/ Peri implantitistreatment”, “polimorfismos IL-1/ Il-1 Gene polymorphisms”, “Marcadores enzimáticos Peri-implantite/Peri-implantitis Biomarkers”.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Peri-implantite IL-1 Polimorfismos genéticos Marcadores enzimáticos peri-implantite