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A importância clínica da vitamina D
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Abstract(s)
A deficiência em vitamina D é um problema de saúde pública que afeta a população de todo o mundo, estimando-se que afete cerca de mil milhões de pessoas de todas as faixas etárias.
No ser humano a vitamina D pode ser obtida de três formas, pela exposição da pele à radiação UVB, pela ingestão alimentar e pela suplementação/medicação. A vitamina D sofre duas hidroxilações até chegar à sua forma ativa. É no fígado que a vitamina D, seja ingerida ou produzida na nossa pele, se metaboliza primeiro em 25-hidroxivitamina, a principal forma circulante, e depois no rim, a vitamina D é novamente metabolizada até tornar na sua forma ativa, 1,25-dihidroxivitamina D. A concentração sérica total de 25(OH)D é usada para definir o status da vitamina D, pois é considerada o indicador mais confiável de seu armazenamento no corpo humano.
Vitamin D deficiency is a public health issue that affects the population all over the world, estimated to affect around one billion people of all ages. In humans, vitamin D can be obtained in three ways, by exposing the skin to UVB radiation, by food and medication. Vitamin D undergoes two hydroxylation's until it reaches its active form. It is in the liver that vitamin D, whether ingested or produced in our skin, is first metabolized into 25-hydroxyvitamin, the main circulating form, and then in the kidney vitamin D is metabolized again until it becomes its active form, 1,25- dihydroxy vitamin D. The total serum concentration of 25(OH)D is used to define the status of vitamin D, as it is considered the most reliable indicator of its storage in the human body.
Vitamin D deficiency is a public health issue that affects the population all over the world, estimated to affect around one billion people of all ages. In humans, vitamin D can be obtained in three ways, by exposing the skin to UVB radiation, by food and medication. Vitamin D undergoes two hydroxylation's until it reaches its active form. It is in the liver that vitamin D, whether ingested or produced in our skin, is first metabolized into 25-hydroxyvitamin, the main circulating form, and then in the kidney vitamin D is metabolized again until it becomes its active form, 1,25- dihydroxy vitamin D. The total serum concentration of 25(OH)D is used to define the status of vitamin D, as it is considered the most reliable indicator of its storage in the human body.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Vitamina D 25-hidroxivitamina 1,25-dihidroxivitamina Deficiência