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Eficácia da matriz de dentina mineralizada para a colocação de implantes : revisão sistemática e meta-análise
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Advisor(s)
Abstract(s)
Introdução: A exodontia é dos procedimentos mais realizados na área da Medicina Dentária. A preservação da crista óssea alveolar tornou-se uma preocupação para permitir diferentes reabilitações, tais como a colocação de implantes dentários. Surgiu com isto a necessidade de estudar diferentes tipos de enxertos ósseos, entre eles o enxerto de matriz de dentina mineralizada.
Objetivos: Avaliar, através de uma revisão sistemática com meta-análise, se enxertos de matriz de dentina mineralizada (MDM) permitem uma preservação da crista alveolar que possibilite a colocação de implantes dentários 4 a 6 meses pós-exodontia.
Materiais e Métodos: As bases de dados PubMed, Google Scholar, Cochrane Library e B-on foram analisadas até abril de 2024. Foi utilizado o algoritmo de pesquisa: ("mineralized dentin matrix" OR "mineralized dentin graft" OR "mineralized dentin") AND ("bone graft" OR "dental graft" OR xenograft OR allograft OR graft OR "autologous graft" OR "autogenous graft") AND ("dental implant" OR "dental implants") e foi realizada uma pesquisa manual. Foram utilizadas duas ferramentas para definir o risco de viés: ROBINS-I e JBI Checklist for Randomized Controlled Trial. Os gráficos do risco de viés foram produzidos nos programas Microsoft Excel e Robvis tool e as metaanálises e meta-regressões no software OpenMetaAnalyst for Windows10.
Resultados: Foram incluídos 3 estudos nesta revisão sistemática e meta-análise, com um total de 45 pacientes e 57 alvéolos. O enxerto de dentina mineralizada induziu formação de novo osso, com uma média de 46.2% (p=0.056) e foi possível a colocação de implante dentário em todos os pacientes.
Conclusões: O enxerto de dentina mineralizada apresenta resultados promissores como enxerto ósseo, no entanto são necessários mais estudos, especialmente ensaios clínicos randomizados de maiores dimensões.
Introduction: Dental extraction is one of the most frequently performed procedures in Dentistry. Alveolar ridge preservation has become a concern to facilitate various rehabilitations, including the placement of dental implants. Consequently, it has become necessary to investigate different types of bone grafts such as mineralized dentin matrix grafts. Objectives: The main objective of this systematic review and meta-analysis is, through scientific evidence, to evaluate if autogenous mineralized dentin matrix (MDM) allows alveolar ridge preservation for implant placement 4 to 6 months after dental extraction. Materials and Methods: PubMed, Google Scholar, Cochrane Library and B-on were searched until April 2024. The search algorithm was ("mineralized dentin matrix" OR "mineralized dentin graft" OR "mineralized dentin") AND ("bone graft" OR "dental graft" OR xenograft OR allograft OR graft OR "autologous graft" OR "autogenous graft") AND ("dental implant" OR "dental implants") and a manual search was also performed. Two risk of bias tools were used: ROBINS-I and JBI Checklist for Randomized Controlled Trial. Risk of bias plots were produced using Microsoft Excel and Robvis tool, and metaanalysis and meta-regressions in OpenMetaAnalyst for Windows10 software. Results: Three studies were included in the systematic review and meta-analysis, with a total of 45 patients and 57 sockets. The results indicate that MDM grafts induced an average of 46.2% (p=0.056) new bone formation, and delayed implant placement was feasible in all patients. Conclusions: Despite the limited available literature, MMD grafting as a bone grafting procedure shows promising results. However, further randomized controlled trials with longer follow-ups are necessary to validate these findings.
Introduction: Dental extraction is one of the most frequently performed procedures in Dentistry. Alveolar ridge preservation has become a concern to facilitate various rehabilitations, including the placement of dental implants. Consequently, it has become necessary to investigate different types of bone grafts such as mineralized dentin matrix grafts. Objectives: The main objective of this systematic review and meta-analysis is, through scientific evidence, to evaluate if autogenous mineralized dentin matrix (MDM) allows alveolar ridge preservation for implant placement 4 to 6 months after dental extraction. Materials and Methods: PubMed, Google Scholar, Cochrane Library and B-on were searched until April 2024. The search algorithm was ("mineralized dentin matrix" OR "mineralized dentin graft" OR "mineralized dentin") AND ("bone graft" OR "dental graft" OR xenograft OR allograft OR graft OR "autologous graft" OR "autogenous graft") AND ("dental implant" OR "dental implants") and a manual search was also performed. Two risk of bias tools were used: ROBINS-I and JBI Checklist for Randomized Controlled Trial. Risk of bias plots were produced using Microsoft Excel and Robvis tool, and metaanalysis and meta-regressions in OpenMetaAnalyst for Windows10 software. Results: Three studies were included in the systematic review and meta-analysis, with a total of 45 patients and 57 sockets. The results indicate that MDM grafts induced an average of 46.2% (p=0.056) new bone formation, and delayed implant placement was feasible in all patients. Conclusions: Despite the limited available literature, MMD grafting as a bone grafting procedure shows promising results. However, further randomized controlled trials with longer follow-ups are necessary to validate these findings.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Matriz de dentina mineralizada Enxerto de dentina Implantes dentários Preservação da crista alveolar