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Antiviral responses induced by Tdap-IPV vaccination are associated with persistent humoral immunity to Bordetella pertussis

2024-03Contributo em revista Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorGillard, Joshua
dc.contributor.authorSuffiotti, Madeleine
dc.contributor.authorBrazda, Peter
dc.contributor.authorVenkatasubramanian, Prashanna B.
dc.contributor.authorVersteegen, Pauline
dc.contributor.authorJonge, Marien I. de
dc.contributor.authorKelly, Dominic
dc.contributor.authorBibi, Sagida
dc.contributor.authorPinto, Marta Valente
dc.contributor.authorSimonetti, Elles
dc.contributor.authorBabiceanu, Mihaela
dc.contributor.authorKettring, Andrew
dc.contributor.authorTeodosio, Cristina
dc.contributor.authorGroot, Ronald de
dc.contributor.authorBerbers, Guy
dc.contributor.authorStunnenberg, Hendrik G.
dc.contributor.authorSchanen, Brian
dc.contributor.authorFenwick, Craig
dc.contributor.authorHuynen, Martijn A.
dc.contributor.authorDiavatopoulos, Dimitri A.
dc.date.accessioned2026-03-18T16:30:49Z
dc.date.available2026-03-18T16:30:49Z
dc.date.issued2024-03
dc.description.abstractMany countries continue to experience pertussis epidemics despite widespread vaccination. Waning protection after booster vaccination has highlighted the need for a better understanding of the immunological factors that promote durable protection. Here we apply systems vaccinology to investigate antibody responses in adolescents in the Netherlands (N = 14; NL) and the United Kingdom (N = 12; UK) receiving a tetanus-diphtheria-acellular pertussis-inactivated poliovirus (Tdap-IPV) vaccine. We report that early antiviral and interferon gene expression signatures in blood correlate to persistence of pertussis-specific antibody responses. Single-cell analyses of the innate response identified monocytes and myeloid dendritic cells (MoDC) as principal responders that upregulate antiviral gene expression and type-I interferon cytokine production. With public data, we show that Tdap vaccination stimulates significantly lower antiviral/type-I interferon responses than Tdap-IPV, suggesting that IPV may promote antiviral gene expression. Subsequent in vitro stimulation experiments demonstrate TLR-dependent, IPV-specific activation of the pro-inflammatory p38 MAP kinase pathway in MoDCs. Together, our data provide insights into the molecular host response to pertussis booster vaccination and demonstrate that IPV enhances innate immune activity associated with persistent, pertussis-specific antibody responses.eng
dc.identifier.citationGillard, J., Suffiotti, M., Brazda, P. et al. Antiviral responses induced by Tdap-IPV vaccination are associated with persistent humoral immunity to Bordetella pertussis. Nat Commun 15, 2133 (2024). https://doi.org/10.1038/s41467-024-46560-w
dc.identifier.doi10.1038/s41467-024-46560-w
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/10400.26/62286
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Nature
dc.relation.hasversionhttps://doi.org/10.1038/s41467-024-46560-w
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectvaccination
dc.subjectpersistent humoral immunity
dc.subjectBordetella pertussis
dc.titleAntiviral responses induced by Tdap-IPV vaccination are associated with persistent humoral immunity to Bordetella pertussiseng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.startPage2133
oaire.citation.titleNature Communications
oaire.citation.volume15
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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