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Is the cat really hypertense?Acute phase proteins as predictors of feline hypertension
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Abstract(s)
A Hipertensão arterial sistémica (HAS) resulta de um aumento persistente dos valores de pressão arterial (PA) e pode ser classificada em situacional, idiopática e secundária. Estudos anteriores indicam que a inflamação tem um papel fundamental na patofisiologia da HAS, que por sua vez pode ser avaliada através das proteínas de fase aguda (PFA), tal como a proteína amilóide A sérica (AAS), a haptoglobina (Hp) e a albumina (ALB).
O objetivo deste estudo foi avaliar o papel das PFA, como biomarcadores inflamatórios em gatos hipertensos.
Este estudo incluiu uma coorte de 38 gatos com idades compreendidas entre os 2-17 anos de idade, submetidos a medição de PA e colheita de sangue e urina, que após consultas de rotina ou vacinação foram considerados saudáveis. Após medição das PA, foram subdivididos em três grupos em função dos valores obtidos: o Grupo A incluiu gatos normotensos (n=7), o Grupo B pré-hipertensos (n=15), por fim o Grupo C incluiu gatos hipertensos (n=16). Foram analisada a concentração de AAS, Hp e ALB, no qual foi encontrada uma diferença significativa entre as concentrações de AAS entre o Grupo A e o Grupo C (P=0,0337).
Este estudo demonstrou que os gatos hipertensos apresentam valores de AAS significativamente mais elevados do que os gatos normotensos. As PFA, nomeadamente a AAS, demonstraram ter potencial para serem utilizadas como biomarcadores no diagnóstico de gatos hipertensos que necessitam de múltiplas medições de PA, permitindo distinguir entre HAS idiopática e situacional, o que apresenta elevado impacto na terapêutica a ser instituída.
Systemic arterial hypertension (SAH) results from persistently increased blood pressure values and can be subcategorised in situational, idiopathic and secondary. Previous studies showed that inflammation plays an important role in SAH, which can be quantified by acute-phase proteins (APPs), as serum amyloid A (SAA), haptoglobin and albumin. The purpose of this study was to evaluate the role of acute phase proteins, as inflammatory biomarkers, in hypertensive cats. This study included a cohort of 38 cats aged 2-17 years old, that came for a routine or vaccination appointment, that were submitted to blood pressure measurement and blood and urine collection that came to an first opinion veterinary clinic for vaccination or a routine appointment and were considered healthy. After blood pressure (BP) measurements, the animals were categorized according to the results, in three groups: Group A included normotensive cats (n=7), the B Group included prehypertensive cats (n=15) and finally, the Group C included hypertensive cats (n=16). Was analysed the concentration of SAA, Hp and ALB, were significant differences were found between the SAA concentration between Group A and Group C (P=0,0337). This study showed that hypertensive cats had significantly higher SAA values in comparison to normotensive group. Acute-phase proteins, namely SAA, seems to have potential to become useful biomarkers on the diagnose of hypertensive cats and to differentiate idiopathic vs. situational hypertension which can dictated the therapeutic approach.
Systemic arterial hypertension (SAH) results from persistently increased blood pressure values and can be subcategorised in situational, idiopathic and secondary. Previous studies showed that inflammation plays an important role in SAH, which can be quantified by acute-phase proteins (APPs), as serum amyloid A (SAA), haptoglobin and albumin. The purpose of this study was to evaluate the role of acute phase proteins, as inflammatory biomarkers, in hypertensive cats. This study included a cohort of 38 cats aged 2-17 years old, that came for a routine or vaccination appointment, that were submitted to blood pressure measurement and blood and urine collection that came to an first opinion veterinary clinic for vaccination or a routine appointment and were considered healthy. After blood pressure (BP) measurements, the animals were categorized according to the results, in three groups: Group A included normotensive cats (n=7), the B Group included prehypertensive cats (n=15) and finally, the Group C included hypertensive cats (n=16). Was analysed the concentration of SAA, Hp and ALB, were significant differences were found between the SAA concentration between Group A and Group C (P=0,0337). This study showed that hypertensive cats had significantly higher SAA values in comparison to normotensive group. Acute-phase proteins, namely SAA, seems to have potential to become useful biomarkers on the diagnose of hypertensive cats and to differentiate idiopathic vs. situational hypertension which can dictated the therapeutic approach.
Description
Keywords
Hipertensão Felino Proteínas de fase aguda Proteína amilóide A sérica Hypertensive Feline Acute-phase proteins Serum amyloid A