Publicação
Exploring botulinum toxin’s impact on masseter hypertrophy : a randomized, triple-blinded clinical trial
| datacite.subject.fos | Ciências Médicas::Ciências da Saúde | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Nobre, Bryanne Brissian de Souza | |
| dc.contributor.author | Rezende, Luciana | |
| dc.contributor.author | Câmara-Souza, Mariana Barbosa | |
| dc.contributor.author | Sanchez-Ayala, Alfonso | |
| dc.contributor.author | Blass, Rodrigo | |
| dc.contributor.author | Carbone, Ana Claudia | |
| dc.contributor.author | Manso, Ana Cristina | |
| dc.contributor.author | Ernberg, Malin | |
| dc.contributor.author | Christidis, Nikolaos | |
| dc.contributor.author | Canales, Giancarlo De la Torre | |
| dc.date.accessioned | 2026-03-31T15:18:42Z | |
| dc.date.available | 2026-03-31T15:18:42Z | |
| dc.date.issued | 2024-06 | |
| dc.description.abstract | The present study aimed to assess the effectiveness and functional adverse effects of a single and multiple injections of botulinum toxin A (BoNT-A) for masseter hypertrophy (MH). Twenty-six women complaining about lower third facial enlargement due to MH, received 75 U of BoNT-A (abobotulinum toxin) in each masseter muscles. After 3 months, patients were randomly assigned to receive a second treatment session of Saline Solution: (G1; n = 11) or BoNT-A: (G2; n = 12). Muscle thickness (ultrasound), electrical activity (electromyography; EMG), masticatory performance, and subjective perception of MH were evaluated. Follow-up was performed at 1, 3 and 6 months. Muscle thickness, EMG activity, and masticatory performance were analyzed using ANOVA two-way and Sidak test as post-hoc. Masticatory performance was analyzed by the Friedman’s test and Mann–Whitney test. Regarding inter-groups comparisons, there was a significant decrease in the left masseter muscle thickness in the G2 group at the 6 month follow-up (p < 0.02). For EMG, significant differences were evident at the 6 month assessment, with higher masseter activity for G1 (p < 0.05). For masticatory performance, no significant differences were observed throughout the study (p > 0.05) and a higher improvement in subjective perception of MH was observed in the 1 month follow-up for G2 (p < 0.05). In conclusion, BoNT-A is effective for MH, however multiple injections cause functional adverse effects in masseter muscle. | eng |
| dc.identifier.citation | de Souza Nobre, B.B., Rezende, L., Barbosa Câmara-Souza, M. et al. Exploring botulinum toxin’s impact on masseter hypertrophy: a randomized, triple-blinded clinical trial. Sci Rep 14, 14522 (2024). https://doi.org/10.1038/s41598-024-65395-5 | |
| dc.identifier.doi | 10.1038/s41598-024-65395-5 | |
| dc.identifier.issn | 2045-2322 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/62551 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Springer Nature | |
| dc.relation.hasversion | https://doi.org/10.1038/s41598-024-65395-5 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Botulinum toxin type A | |
| dc.subject | Masseter hypertrophy | |
| dc.subject | Muscle thickness | |
| dc.subject | Masticatory performance | |
| dc.title | Exploring botulinum toxin’s impact on masseter hypertrophy : a randomized, triple-blinded clinical trial | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.startPage | 14522 | |
| oaire.citation.title | Scientific Reports | |
| oaire.citation.volume | 14 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |