Publication
Uterine Adenocarcinoma in pet rabbits: a review
| dc.contributor.advisor | Carmo, AnƔlia Georgina Vital | |
| dc.contributor.advisor | Vieira, Ana LuĆsa Nobre de Matos Pereira | |
| dc.contributor.author | e Silva, Carolina Salgueiro Costa | |
| dc.date.accessioned | 2016-12-14T16:53:49Z | |
| dc.date.available | 2016-12-14T16:53:49Z | |
| dc.date.issued | 2015-06-30 | |
| dc.description.abstract | The uterine adenocarcinoma is a slow growing malignant tumour that affects 50-80% of pet rabbits over 4 years old, having age as its major risk factor. The mechanisms underlying the development of this tumour are not completely understood and some of the existing studies presented contradictory results. In fact, in rabbits there is not an adequate classification of these tumours and until now the cellular and molecular features were not fully investigated. Regarding treatment and until today, ovariohysterectomy is the only effective treatment. Without it, this neoplasia leads to the female rabbitās death within 1 to 2 years after the appearance of symptoms and metastasis. In spite of the fact that these tumours could in other species be treated by chemotherapy, radiotherapy and hormonal therapy, in rabbits these treatments were mainly used in laboratory animals and therefore, there is no data regarding the adequate protocol. The limited studies available and the existing doubts around the development of the uterine adenocarcinoma in rabbits show that further investigation is necessary to provide other ways to make an accurate diagnosis, to establish an adequate treatment protocol and to determine the prognosis. | pt_PT |
| dc.description.abstract | O adenocarcinoma uterino Ć© um tumor maligno de crescimento lento que afecta 50-80% dos coelhos com mais de 4 anos, sendo a idade o principal factor de risco para esta neoplasia. Os mecanismos que envolvem o desenvolvimento deste tumor nĆ£o estĆ£o totalmente clarificados e alguns estudos apresentam resultados contraditĆ³rios. Actualmente, a classificaĆ§Ć£o bem como a caracterizaĆ§Ć£o celular e molecular do adenocarcinoma uterino nesta espĆ©cie permanece pouco aprofundada. AtĆ© Ć data, a ovariohisterectomia Ć© o Ćŗnico tratamento eficaz e, na sua ausĆŖncia, o adenocarcinoma provoca a morte num perĆodo de 1 a 2 anos apĆ³s o aparecimento de sintomas e metĆ”stases. Em diferentes espĆ©cies, a quimioterapia, a radioterapia e a terapia hormonal sĆ£o outras opƧƵes de tratamento, no entanto nos coelhos a sua aplicaĆ§Ć£o Ć© apenas experimental e associada a animais de biotĆ©rio, nĆ£o existindo informaĆ§Ć£o suficiente para o estabelecimento de protocolos adequados Ć espĆ©cie. O nĆŗmero limitado de estudos e as permanentes dĆŗvidas associadas ao desenvolvimento desta patologia em coelhos evidencia a necessidade de investimento na investigaĆ§Ć£o, a qual poderĆ” revelar novas formas de diagnĆ³stico e tratamento e, consequentemente, alterar o prognĆ³stico. | pt_PT |
| dc.identifier.tid | 201098512 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.26/16794 | |
| dc.language.iso | eng | pt_PT |
| dc.subject | Rabbit | pt_PT |
| dc.subject | Female | pt_PT |
| dc.subject | Uterine adenocarcinoma | pt_PT |
| dc.subject | Tumour | pt_PT |
| dc.subject | Coelha | pt_PT |
| dc.subject | FĆŖmea | pt_PT |
| dc.subject | Adenocarcinoma uterino | pt_PT |
| dc.subject | Tumor | pt_PT |
| dc.title | Uterine Adenocarcinoma in pet rabbits: a review | pt_PT |
| dc.type | master thesis | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | masterThesis | pt_PT |
| thesis.degree.name | Medicina VeterinƔria | pt_PT |