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A prevalência das alterações vasculares no carcinoma das células escamosas na mucosa oral : revisão sistemática
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Advisor(s)
Abstract(s)
Introdução: O Carcinoma das Células Escamosas (CCE) é um dos tipos mais comuns de cancro na cavidade oral devido à sua agressividade, potencial de invasão local e metástase. O diagnóstico precoce e tratamento adequado são essenciais para garantir a melhoria dos resultados clínicos. Compreender a vascularização do CCE é essencial para entender o seu crescimento, disseminação e possíveis opções terapêuticas.
Objetivo: Analisar qualitativamente as alterações vasculares no carcinoma das células escamosas da mucosa oral em adultos.
Métodos: A pesquisa foi realizada nas bases de dados: PubMed, Cochrane, Scopus e Embase. Após análise dos títulos e resumos, foram lidos os textos de forma integral e os artigos foram selecionando conforme os critérios de inclusão estabelecidos.
Resultados: Observou-se um maior número de alterações vasculares em estadios mais avançados do CCE, estimuladas por diversos fatores de crescimento e citocinas produzidas tanto pelas células tumorais quanto pelo microambiente tumoral. Existem vários fatores que, em níveis elevados, promovem a angiogénese no CCE. A angiogénese fornece oxigénio e nutrientes ao tumor, permitindo o seu crescimento e disseminação.
Conclusão: As alterações vasculares são significativamente mais prevalentes no CCE da mucosa oral em comparação com a mucosa oral normal. A densidade média dos microvasos correlaciona-se diretamente com a agressividade do tumor, potencial metastático e prognóstico.
Introduction: Squamous cell carcinoma (SCC) is one of the most common types of cancer in the oral cavity due to its aggressiveness, potential for local invasion and metastasis. Early diagnosis and appropriate treatment are essential to ensure improved clinical outcomes. Understanding the vascularisation of SCC is essential to understanding their growth, dissemination and possible therapeutic options. Objective: To qualitatively analyse vascular alterations in squamous cell carcinoma of the oral mucosa in adults. Methods: The search was carried out in the following databases: PubMed, Cochrane, Scopus and Embase. After analysing the titles and abstracts, the texts were read in full and the articles were selected according to the established inclusion criteria. Results: A greater number of vascular alterations have been observed in more advanced stages of SCC, stimulated by various growth factors and cytokines produced by both tumour cells and the tumour microenvironment. There are several factors that at high levels promote angiogenesis in SCC. Angiogenesis provides the tumour with oxygen and nutrients, allowing it to grow and spread. Conclusion: Vascular alterations are significantly more prevalent in SCC of the oral mucosa compared to normal oral mucosa. Mean microvessel density correlates directly with tumour aggressiveness, metastatic potential and prognosis.
Introduction: Squamous cell carcinoma (SCC) is one of the most common types of cancer in the oral cavity due to its aggressiveness, potential for local invasion and metastasis. Early diagnosis and appropriate treatment are essential to ensure improved clinical outcomes. Understanding the vascularisation of SCC is essential to understanding their growth, dissemination and possible therapeutic options. Objective: To qualitatively analyse vascular alterations in squamous cell carcinoma of the oral mucosa in adults. Methods: The search was carried out in the following databases: PubMed, Cochrane, Scopus and Embase. After analysing the titles and abstracts, the texts were read in full and the articles were selected according to the established inclusion criteria. Results: A greater number of vascular alterations have been observed in more advanced stages of SCC, stimulated by various growth factors and cytokines produced by both tumour cells and the tumour microenvironment. There are several factors that at high levels promote angiogenesis in SCC. Angiogenesis provides the tumour with oxygen and nutrients, allowing it to grow and spread. Conclusion: Vascular alterations are significantly more prevalent in SCC of the oral mucosa compared to normal oral mucosa. Mean microvessel density correlates directly with tumour aggressiveness, metastatic potential and prognosis.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Mucosa oral Angiogénese Carcinoma das células escamosas Alterações vasculares