Ovarian sertoli-leydig cell tumour with heterologous elements of gastrointestinal type associated with elevated serum alpha-fetoprotein level: an unusual case and literature review

Horta, Mariana; Cunha, Teresa Margarida; Marques, Rita Canas; Félix, Ana

http://hdl.handle.net/10400.26/14946

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Authors

Horta, Mariana

Cunha, Teresa Margarida

Marques, Rita Canas

Félix, Ana

Abstract(s)

Here we describe the case of a 19-year-old woman with a poorly differentiated ovarian Sertoli-Leydig cell tumor and an elevated serum alphafetoprotein level. The patient presented with diffuse abdominal pain and bloating. Physical examination, ultrasound, and magnetic resonance imaging revealed a right ovarian tumor that was histopathologically diagnosed as a poorly differentiated Sertoli-Leydig cell tumor with heterologous elements. Her alpha-fetoprotein serum level was undetectable after tumor resection. Sertoli-Leydig cell tumors are rare sex cord-stromal tumors that account for 0.5% of all ovarian neoplasms. Sertoli-Leydig cell tumors tend to be unilateral and occur in women under 30 years of age. Although they are the most common virilizing tumor of the ovary, about 60% are endocrineinactive tumors. Elevated serum levels of alpha-fetoprotein are rarely associated with Sertoli-Leydig cell tumors, with only approximately 30 such cases previously reported in the literature. The differential diagnosis should include common alpha-fetoprotein-producing ovarian entities such as germ cell tumors, as well as other non-germ cell tumors that have been rarely reported to produce this tumor marker.

URI

http://hdl.handle.net/10400.26/14946

Citation

Mariana Horta; Teresa Margarida Cunha; Rita Canas Marques; Ana Félix. Ovarian Sertoli-Leydig Cell Tumour with Heterologous Elements of Gastrointestinal Type Associated with Elevated Serum Alpha-Fetoprotein Level: An Unusual Case and Literature Review, Journal of Radiology Case Reports, 8, 11, 30-41, 2014.