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Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012

2014-05Journal article Open access
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dc.contributor.authorPalladino, Claudia
dc.contributor.authorBriz, Verónica
dc.contributor.authorBellón, José María
dc.contributor.authorCliment, Francisco J.
dc.contributor.authorDe Ory, Santiago J.
dc.contributor.authorMellado, María José
dc.contributor.authorNavarro, María Luisa
dc.contributor.authorRamos, José T.
dc.contributor.authorTaveira, Nuno
dc.contributor.authorDe José, María Isabel
dc.contributor.authorMunõz-Fernandes, María Ángeles
dc.contributor.authorCoRISpeS-Madrid Cohort Working Group
dc.date.accessioned2014-05-29T12:00:32Z
dc.date.available2014-05-29T12:00:32Z
dc.date.issued2014-05
dc.descriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Users must also make clear the license terms under which the work was published.
dc.description.abstract"Objectives: To investigate the duration of sequential HAART regimens and predictors of first-line regimen discontinuation among HIV-1 vertically infected children and adolescents. Design: Multicentre survey of antiretroviral-naı¨ve patients enrolled in the HIV-Paediatric Cohor,t CoRISpeS-Madrid Cohort, Spain. Methods: Patients with a follow-up of $1 month spent on HAART, with available baseline CD4 count and HIV-viral load (VL) were included. Time spent on sequential HAART regimens was estimated and multivariable regression was used to identify predictors of time to first-line regimen discontinuation. Results: 104 patients were followed for a median 8 years after starting HAART among 1996–2012; baseline %CD4 was 21.5 (12.3–34.0)and viral load was 5.1 (4.6–5.6) log10 copies/mL. Patients received a mean of 1.9 regimens. Median time on firstline HAART (n = 104) was 64.5 months; second HAART (n = 56) 69.8 months; and third HAART (n = 21) 66.5 months. Eleven (11%) patients were lost to follow-up while on first-line HAART and 54% discontinued (cumulative incidence of 16% and 38% by 1 and 3-year, respectively). The main predictor of first-line regimen discontinuation was suboptimal adherence to antiretrovirals (AHR: 2.60; 95% CI: 1.44–4.70). Conclusions: Adherence to therapy was the main determinant of the duration of the first-line HAART regimen in children. It is important to identify patients at high risk for non-adherence, such as very young children and adolescents, in provide special care and support to those patients."por
dc.identifier.citationPLoS ONE 9(5): e96307. doi:10.1371/journal.pone.0096307por
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.26/6427
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherPLOSpor
dc.relationMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
dc.relation.publisherversionhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0096307por
dc.subjectAntiretroviral therapypor
dc.subjectHIV-1por
dc.subjectHighly-active antiretroviral therapypor
dc.subjectAdolescentspor
dc.subjectChildrenpor
dc.subjectMadridpor
dc.titleDeterminants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012por
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-EPI%2F122400%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-FAR%2F115290%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F77448%2F2011/PT
oaire.citation.startPagee96307por
oaire.citation.titlePLoS ONEpor
oaire.citation.volume9 (5)por
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isProjectOfPublicationc3b60260-41c1-4212-93cd-191d5b2e6133
relation.isProjectOfPublication15aded3d-70a1-4e02-8508-f5e6a4e56f9a
relation.isProjectOfPublication6820802c-e181-4622-be67-b4e7af9d2ba1
relation.isProjectOfPublication.latestForDiscoveryc3b60260-41c1-4212-93cd-191d5b2e6133

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