Publication
Periodontitis impact in interleukin-6 serum levels in solid organ transplanted patients: a systematic review and meta-analysis
| datacite.subject.fos | Ciências Médicas | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Machado, Vanessa | |
| dc.contributor.author | Botelho, João | |
| dc.contributor.author | Lopes, Joana | |
| dc.contributor.author | Patrão, Mariana | |
| dc.contributor.author | Alves, Ricardo | |
| dc.contributor.author | Chambrone, Leandro | |
| dc.contributor.author | Alcoforado, Gil | |
| dc.contributor.author | Mendes, José João | |
| dc.date.accessioned | 2025-07-30T11:43:37Z | |
| dc.date.available | 2025-07-30T11:43:37Z | |
| dc.date.issued | 2020-04 | |
| dc.description.abstract | This systematic review aimed to investigate the influence of periodontitis on post-transplant IL-6 serum levels of solid organ transplanted patients as compared to healthy subjects. Four databases (PubMed, Scholar, EMBASE, and CENTRAL) were searched up to February 2020 (PROSPERO CRD42018107817). Case-control and cohort studies on the association of IL-6 serum levels with a periodontal status of patients after solid organ transplantation were included. The risk of bias of observational studies was assessed through the Newcastle-Ottawa Scale (NOS). Random effects meta-analyses were thoroughly conducted. GRADE assessment provided quality evidence. Four case-control studies fulfilled the inclusion criteria (274 transplant recipients and 146 healthy controls), all of low risk of bias. Meta-analyses revealed significantly higher IL-6 levels in transplanted patients than healthy individuals with low-quality evidence (Mean Difference (MD): 2.55 (95% confidence interval (CI): 2.07, 3.03)). Transplanted patients with periodontitis have higher serum IL-6 levels than transplanted patients without periodontitis with moderate quality evidence (MD: 2.20 (95% CI: 1.00, 3.39)). We found low-quality evidence of higher IL-6 levels than healthy patients in patients with heart and kidney transplant. In these transplanted patients, there was moderate quality evidence that periodontitis is associated with higher IL-6 serum levels. Future research should consider the impact of such a difference in organ failure and systemic complications. | eng |
| dc.identifier.citation | Machado, V., Botelho, J., Lopes, J., Patrão, M., Alves, R., Chambrone, L., Alcoforado, G., & Mendes, J. J. (2020). Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis. Diagnostics, 10(4), 184. https://doi.org/10.3390/diagnostics10040184 | |
| dc.identifier.doi | 10.3390/diagnostics10040184 | |
| dc.identifier.issn | 2075-4418 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/58266 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation.hasversion | https://doi.org/10.3390/diagnostics10040184 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Periodontitis | |
| dc.subject | Periodontal diseases | |
| dc.subject | Transplantation | |
| dc.subject | interleukin-6 | |
| dc.subject | systematic review | |
| dc.title | Periodontitis impact in interleukin-6 serum levels in solid organ transplanted patients: a systematic review and meta-analysis | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 4 | |
| oaire.citation.startPage | 184 | |
| oaire.citation.title | Diagnostics | |
| oaire.citation.volume | 10 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |