Periodontitis impact in interleukin-6 serum levels in solid organ transplanted patients: a systematic review and meta-analysis

Machado, Vanessa; Botelho, João; Lopes, Joana; Patrão, Mariana; Alves, Ricardo; Chambrone, Leandro; Alcoforado, Gil; Mendes, José João

http://hdl.handle.net/10400.26/58266

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
Artigo_JJMendes_2020_13.pdf		1.14 MB	Adobe PDF	Download

Send Feedback

Authors

Abstract(s)

This systematic review aimed to investigate the influence of periodontitis on post-transplant IL-6 serum levels of solid organ transplanted patients as compared to healthy subjects. Four databases (PubMed, Scholar, EMBASE, and CENTRAL) were searched up to February 2020 (PROSPERO CRD42018107817). Case-control and cohort studies on the association of IL-6 serum levels with a periodontal status of patients after solid organ transplantation were included. The risk of bias of observational studies was assessed through the Newcastle-Ottawa Scale (NOS). Random effects meta-analyses were thoroughly conducted. GRADE assessment provided quality evidence. Four case-control studies fulfilled the inclusion criteria (274 transplant recipients and 146 healthy controls), all of low risk of bias. Meta-analyses revealed significantly higher IL-6 levels in transplanted patients than healthy individuals with low-quality evidence (Mean Difference (MD): 2.55 (95% confidence interval (CI): 2.07, 3.03)). Transplanted patients with periodontitis have higher serum IL-6 levels than transplanted patients without periodontitis with moderate quality evidence (MD: 2.20 (95% CI: 1.00, 3.39)). We found low-quality evidence of higher IL-6 levels than healthy patients in patients with heart and kidney transplant. In these transplanted patients, there was moderate quality evidence that periodontitis is associated with higher IL-6 serum levels. Future research should consider the impact of such a difference in organ failure and systemic complications.

Keywords

Periodontitis Periodontal diseases Transplantation interleukin-6 systematic review

URI

http://hdl.handle.net/10400.26/58266

Citation

Machado, V., Botelho, J., Lopes, J., Patrão, M., Alves, R., Chambrone, L., Alcoforado, G., & Mendes, J. J. (2020). Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis. Diagnostics, 10(4), 184. https://doi.org/10.3390/diagnostics10040184