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Publication
Medicina personalizada no tratamento com estatinas
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Abstract(s)
Uma das principais causas de morte a nível mundial é a doença cardiovascular sendo as dislipidemias um fator de risco importante para esta situação patológica.
As Estatinas são um dos principais grupos de fármacos utilizados para o tratamento de dislipidemias. Fármacos com eficácia comprovada e bem tolerados pelo organismo, desenvolvendo por vezes, efeitos adversos graves e que podem levar á morte.
Vários são os polimorfismos em genes que atuam como transportadores ou metabolizadores das Estatinas e que estão associados ás alterações na eficácia e segurança da terapêutica e que nesta monografia se faz revisão.
A medicina personalizada é um conceito importante nos dias de hoje, pois permite através de testes farmacogenómicos perceber qual a pré-disposição do individuo para o desenvolvimento de efeitos adversos, e até da resposta a fármacos.
One of the main death causes worldwide is cardiovascular disease and dyslipidemias are an important risk factor for this pathological situation. Statins are the main group of drugs used for the treatment of dyslipidemias. Drugs with proven efficacy and well tolerated by the body, sometimes developing serious adverse effects that can lead to death. Several polymorphisms in genes that act as statin transporters or metabolizers and are associated with changes in the efficacy and safety of therapy and that in this monograph is reviewed. Personalized medicine is an important concept these days, as it allows through pharmacogenomic tests to understand which individual predisposition to develop adverse effects, and even drug response.
One of the main death causes worldwide is cardiovascular disease and dyslipidemias are an important risk factor for this pathological situation. Statins are the main group of drugs used for the treatment of dyslipidemias. Drugs with proven efficacy and well tolerated by the body, sometimes developing serious adverse effects that can lead to death. Several polymorphisms in genes that act as statin transporters or metabolizers and are associated with changes in the efficacy and safety of therapy and that in this monograph is reviewed. Personalized medicine is an important concept these days, as it allows through pharmacogenomic tests to understand which individual predisposition to develop adverse effects, and even drug response.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Estatinas Inibidores da HMG-CoA redutase Medicina personalizada Miotoxicidade Dislipidemias ABCC2 ABCG2 CYP2C9 CYP2D6 CYP3A4 CYP3A5 UGT1A3