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Potencial de malignização de lesões orais de líquen plano : uma revisão umbrella
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Orientador(es)
Resumo(s)
O Líquen Plano Oral (LPO) é uma doença crónica autoimune de carácter inflamatório, relativamente comum e de etiologia desconhecida.
Objetivo: Avaliar as provas científicas disponíveis à data de hoje à cerca da transformação maligna do Líquen Plano Oral (LPO) por meio de uma Revisão Umbrela a fim de avaliar a consistência e qualidade da evidência científica atual.
Materiais e Métodos: O presente estudo foi desenvolvido de acordo com o método Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). O protocolo de revisão foi aprovado a priori por todos os autores e submetido online na plataforma PROSPERO (CRD42022379064). Foram definidos e aplicados critérios de inclusão e exclusão para os estudos encontrados. As bases de dados utilizadas foram as seguintes: PubMed, Web of Science, Scopus, Cochrane, Lilacs. Não foi aplicada qualquer restrição ao idioma e ano de publicação dos estudos.
Resultados: Das 190 referências potencialmente relevantes, foram eliminadas 49 referências duplicadas sobrando 141 referências para posterior leitura do título do abstract. Após leitura dos mesmos foram excluídos 114 artigos, restando assim 26 artigos para leitura integral. Posteriormente, aplicámos os critérios de inclusão e exclusão, tendo sido incluídos 12 artigos na umbrella review. Foi utilizada a ferramenta Assessing the Methodological Quality of Systematic Reviews (AMSTAR 2) para determinar a qualidade metodológica dos estudos incluídos. Todos os estudos revelaram ter baixa qualidade.
Conclusão: Existe falta de unanimidade em relação ao potencial de malignização do LPO, o diagnóstico requer uma associação de caraterísticas clínicas e histopatológicas, as quais não têm sido aplicadas de forma uniforme entre investigadores. A avaliação do potencial de malignização do LPO é altamente dependente da qualidade metodológica inerente ao estudo. Para uma avaliação mais exata da transformação maligna do LPO a aplicação dos critérios de qualidade metodológica propostos neste estudo seria essencial.
Oral Lichen Planus (OLP) is a chronic autoimmune disease of inflammatory character, relatively common and of unknown etiology. Objective: To evaluate the scientific evidence available to date on the malignant transformation of Oral Lichen Planus (OLP) by means of an umbrella review to assess the consistency of the current scientific evidence. Materials and Methods: The present study was developed using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) method. The review protocol was approved a priori by all authors and submitted online to the PROSPERO platform (CRD42022379064). Inclusion and exclusion criteria were defined and applied to the studies found. The following databases were used PubMed, Web of Science, Scopus, Cochrane, Lilacs. There were no restrictions on the language and year of publication of the studies. Results: Of the 190 potentially relevant references, 49 duplicate were eliminated, leaving 141 references for further reading of the title and abstract. After reading, 114 articles were excluded, leaving 26 for full reading. The inclusion and exclusion criteria were then applied, and 12 articles were included in the Umbrella Review. The Assessing the Methodological Quality of Systematic Reviews (AMSTAR 2) tool was used to assess the methodological quality of the included studies. All studies were found to be of low quality. Conclusion: There is no consensus on the malignant potential of LPO, and the diagnosis requires a combination of clinical and histopathological features that have not been consistently applied by investigators.The assessment of the malignant potential of LPO is highly dependent on the methodological quality of the study design. For a more accurate assessment of the malignant transformation of LPO, the application of the methodological quality criteria proposed in this study would be essential.
Oral Lichen Planus (OLP) is a chronic autoimmune disease of inflammatory character, relatively common and of unknown etiology. Objective: To evaluate the scientific evidence available to date on the malignant transformation of Oral Lichen Planus (OLP) by means of an umbrella review to assess the consistency of the current scientific evidence. Materials and Methods: The present study was developed using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) method. The review protocol was approved a priori by all authors and submitted online to the PROSPERO platform (CRD42022379064). Inclusion and exclusion criteria were defined and applied to the studies found. The following databases were used PubMed, Web of Science, Scopus, Cochrane, Lilacs. There were no restrictions on the language and year of publication of the studies. Results: Of the 190 potentially relevant references, 49 duplicate were eliminated, leaving 141 references for further reading of the title and abstract. After reading, 114 articles were excluded, leaving 26 for full reading. The inclusion and exclusion criteria were then applied, and 12 articles were included in the Umbrella Review. The Assessing the Methodological Quality of Systematic Reviews (AMSTAR 2) tool was used to assess the methodological quality of the included studies. All studies were found to be of low quality. Conclusion: There is no consensus on the malignant potential of LPO, and the diagnosis requires a combination of clinical and histopathological features that have not been consistently applied by investigators.The assessment of the malignant potential of LPO is highly dependent on the methodological quality of the study design. For a more accurate assessment of the malignant transformation of LPO, the application of the methodological quality criteria proposed in this study would be essential.
Descrição
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Palavras-chave
Líquen plano oral Maligno Revisão sistemática Meta-análise