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Canabinóides : estrutura química, efeitos farmacológicos e utilização terapêutica
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Abstract(s)
Nos últimos anos a Canábis L. Sativa tem sido o foco da atenção da comunidade científica em todo o mundo, devido às potenciais aplicações de um dos seus principais componentes – os canabinóides. De facto, os efeitos terapêuticos demonstrados com a sua utilização no tratamento de diversas patologias têm suscitado um interesse crescente por parte de muitos investigadores.
A sua interação com o sistema endocanabinóide tem revelado evidências do envolvimento dos canabinóides em diversos processos fisiológicos como a dor, náuseas, vómitos, esclerose múltipla entre outros. Embora a sua utilização seja controversa, existe um número crescente de estudos que comprovam que os canabinóides podem ser utilizados como terapêutica inicial para diversas patologias. No entanto, é ainda necessária mais investigação para fundamentar a sua aplicação terapêutica. Assim, ao longo deste trabalho, apresentou-se uma visão das diferentes formas como os canabinóides podem ser utilizados para o tratamento de diversas doenças.
In recent years Cannabis L. Sativa has been the focus of attention of the scientific community around the world due to the potential applications of one of its main components - cannabinoids. In fact, the therapeutic effects shown by its use in the treatment of various pathologies have raised increasing interest from many researchers. Their interaction with the endocanabinoid system has revealed evidence of the involvement of cannabinoids in several physiological processes such as pain, nausea, vomiting, multiple sclerosis among others. Although their use is controversial, there are an increasing number of studies that prove that cannabinoids can be used as initial therapy for several pathologies. However, further research is still needed to substantiate their therapeutic application. Thus, throughout this work, a vision of the different ways cannabinoids can be used for the treatment of several diseases has been presented.
In recent years Cannabis L. Sativa has been the focus of attention of the scientific community around the world due to the potential applications of one of its main components - cannabinoids. In fact, the therapeutic effects shown by its use in the treatment of various pathologies have raised increasing interest from many researchers. Their interaction with the endocanabinoid system has revealed evidence of the involvement of cannabinoids in several physiological processes such as pain, nausea, vomiting, multiple sclerosis among others. Although their use is controversial, there are an increasing number of studies that prove that cannabinoids can be used as initial therapy for several pathologies. However, further research is still needed to substantiate their therapeutic application. Thus, throughout this work, a vision of the different ways cannabinoids can be used for the treatment of several diseases has been presented.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Canábis L. Sativa Canabinóides Biossíntese dos canabinóides Sistema endocanabinóide Aplicações terapêuticas