Browsing by Issue Date, starting with "2016-06-23"
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- The CNS MOVING VOICE program: Implementation of a dual voice and physical exercise program for Parkinson disease - an applicability studyPublication . Loureiro, Rita; Domingos, Josefa; Peralta, Diana; Dean, John; Godinho, Catarina; Ferreira, Joaquim J."Objective: To test the applicability of a rehabilitation program for people with Parkinson’s disease that combines speech and motor exercises (The CNS Moving Voice program)."
- Equine embryo transfer: the effect of semen processing and donor mare management on recovery ratesPublication . Correia, Sónia Cristina Gonçalves; Duarte, Sofia Alexandra Giestas Cancela; Pereira, Rosa Maria Lino NetoEmbryo transfer (ET) is a biotechnology that allows to get more than one foal from a single mare during a breading season and also to prevent the removal of mares from their competition careers. Nevertheless, to achieve a successful outcome, the association of many factors must be considered such as the management of donor and recipient mares, the stallions and the veterinarian´s experience. The aims of this study were to evaluate (1) if some of characteristics related to the donor mares such as the breed and the reproductive status, may influence the embryo recovery; (2) if climate and different donor mares location may have impact in breeding programs; (3) the effect of some reproductive techniques and embryo transfer methodologies such as the day of uterine flushing, the type of semen, the stallion and the moment of inseminations and transfer as potential effectors of success. To achieve the objectives pointed out, one hundred and fifty six uterine flushes and eighty eight embryo transfers were performed. Obtained results showed higher embryo recovery rates at day 8 (61.1%) and an overall pregnancy rate of 62.2%. An influence of the month of the year (P=0.04) and of the type of semen (fresh or frozen; P=0.03) on the number of positive embryo collections were identified. No other significant effects upon the remaining determinants under testing were observed, although stallions were responsible for inducing 11% of the variability within embryo recovery rates. In conclusion, the main factors that had a great influence in this embryo transfer program were the type of semen and the day and month of the uterine flushing procedure. The use of fresh semen for donor mares insemination and recovery at day 8 increased the number of embryos that were collected during this period, although lower results were obtained in July-August. These procedures should be consider and implement in mare embryo transfer centres.
- Applicability study of a multitask cognitive and motor exercise program for individuals with Parkinson´s disease: The COGWEB® MOVE ProgramPublication . Domingos, Josefa; Peralta, Diana; Loureiro, Rita; Godinho, Catarina; Pais, Joana; Cruz, Vitor Tedim; Ferreira, Joaquim J."Objective: To test the applicability of a new rehabilitation program for people with Parkinson´s disease combining web-based cognitive training with motor exercises (COGWEB ® CNS Move Program)."
- Descentralização: Implicações na Gestão Municipal - Uma aplicação na Ilha de Santiago, Cabo VerdePublication . Furtado Afonso, Adriano; Dias, ÁlvaroA presente dissertação centrou-se na análise do programa de descentralização em Cabo Verde e as suas implicações na gestão municipal, particularmente nos municípios da Ilha de Santiago. Os objectivos foram avaliar a percepção da participação dos cidadãos na elaboração de políticas, nas decisões locais, na fiscalização e controlo da acção dos dirigentes municipais, estudar o conhecimento dos mecanismos de participação, analisar o nível de dependência financeira em relação ao governo central e discutir a relação entre as capacidades técnicas municipais e a qualidade das decisões. Com base em questionários aplicados aos cidadãos e autarcas de três municípios da Ilha e, nos documentos oficiais e estudos já publicados, constatou-se que a participação dos cidadãos na gestão municipal é limitada e, por conseguinte, um fraco controlo, por parte dos cidadãos, sobre a acção dos governantes. Outrossim, a capacidade dos municípios em gerar receitas próprias é limitada, e sua dependência face à administração central é muito elevada, e uma certa carência em termos de pessoal técnico.
- Antidepressants detection and quantification in whole blood samples by GC–MS/MS, for forensic purposesPublication . Truta, Liliana; Castro, André Lobo; Tarelho, Sónia; Costa, Pedro; Sales, M. Goreti F.; Teixeira, Helena M.Depression is among the most prevalent psychiatric disorders of our society, leading to an increase in antidepressant drug consumption that needs to be accurately determined in whole blood samples in Forensic Toxicology Laboratories. For this purpose, this work presents a new gas chromatography tandem mass spectrometry (GC–MS/MS) method targeting the simultaneous and rapid determination of 14 common Antidepressants in whole blood: 13 Antidepressants (amitriptyline, citalopram, clomipramine, dothiepin, fluoxetine, imipramine, mianserin, mirtazapine, nortryptiline, paroxetine, sertraline, trimipramine and venlafaxine) and 1 Metabolite (N-desmethylclomipramine). Solid-phase extraction was used prior to chromatographic separation. Chromatographic and MS/MS parameters were selected to improve sensitivity, peak resolution and unequivocal identification of the eluted analyte. The detection was performed on a triple quadrupole tandem MS in selected ion monitoring (SIM) mode in tandem, using electronic impact ionization. Clomipramine-D3 and trimipramine-D3 were used as deutered internal standards. The validation parameters included linearity, limits of detection, lower limit of quantification, selectivity/ specificity, extraction efficiency, carry-over, precision and robustness, and followed internationally accepted guidelines. Limits of quantification and detection were lower than therapeutic and subtherapeutic concentration ranges. Overall, the method offered good selectivity, robustness and quick response (<16 min) for typical concentration ranges, both for therapeutic and lethal levels.