Browsing by Issue Date, starting with "2015-08"
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- A dimensão economica do acordo nuclear iranianoPublication . Galamas, Francisco
- A Arte de traçar respostas inclusivas : as potencialidades das artes plásticas na promoção do desenvolvimento de competências cognitivas e emocionaisPublication . Cabral, Maria Paula Porto RoquePara que a escola possa oferecer respostas adequadas à diversidade caraterizante do seu público-alvo o professor precisa de implementar contextos educativos englobando toda uma gama de opções de aprendizagem, motivantes e capazes de responder a cada um e a todos os alunos. Foi no contexto da diversidade – que desafia a escola a traçar respostas inclusivas – que surgiram as questões que procuramos investigar neste trabalho. Através destas questões pretendemos conhecer as perceções dos professores sobre a importância das artes plásticas no desenvolvimento cognitivo dos alunos, em geral e com NEE, em particular; e conhecer as perceções dos professores sobre a importância das artes plásticas no desenvolvimento emocional dos alunos, em geral e com NEE, em particular. Pretendemos defender a importância de dar um lugar relevante à educação pela arte no currículo, no sentido de serem proporcionadas oportunidades de participação e de desenvolvimento de competências a cada um e a todos os alunos, numa perspetiva de inclusão escolar e de otimização de todas as potencialidades de cada indivíduo, permitindo uma resolução crítica e criativa de problemas no trabalho e... na vida, para todos, sem exceção.
- Uma pequena potência é uma potência? O papel e a resiliência das pequenas e médias potências na Grande Guerra de 1914-1918Publication . Saraiva, Maria Francisca; Duarte, António Paulo; Afonso, Aniceto; Tuna, Cátia; Dhenin, Miguel; Mendonça, Valterian; Matos, Sérgio Ricardo Reis; Zary, Julio Cezar Fidalgo; Maximiano, César Campiani; Almeida, Francisco Eduardo Alves de; Vaz-Pinto, Raquel; Rodrigues, Ana Duarte
- Segurança coletiva : desafios no âmbito das Nações UnidasPublication . Santana, Joaquim
- Prediction of peptide and protein propensity for amyloid formationPublication . Família, Carlos; Dennison, Sarah R.; Quintas, Alexandre; Phoenix, David A."Understanding which peptides and proteins have the potential to undergo amyloid formation and what driving forces are responsible for amyloid-like fiber formation and stabilization remains limited. This is mainly because proteins that can undergo structural changes, which lead to amyloid formation, are quite diverse and share no obvious sequence or structural homology, despite the structural similarity found in the fibrils. To address these issues, a novel approach based on recursive feature selection and feed-forward neural networks was undertaken to identify key features highly correlated with the self-assembly problem. This approach allowed the identification of seven physicochemical and biochemical properties of the amino acids highly associated with the self-assembly of peptides and proteins into amyloid-like fibrils (normalized frequency of β-sheet, normalized frequency of β-sheet from LG, weights for β-sheet at the window position of 1, isoelectric point, atom-based hydrophobic moment, helix termination parameter at position j+1 and ΔG° values for peptides extrapolated in 0 M urea). Moreover, these features enabled the development of a new predictor (available at http://cran.r-project.org/web/packages/appnn/index.html) capable of accurately and reliably predicting the amyloidogenic propensity from the polypeptide sequence alone with a prediction accuracy of 84.9 % against an external validation dataset of sequences with experimental in vitro, evidence of amyloid formation."
- Traqueoesophageal fistula patients fed through percutaneous endoscopic gastrostomy/gastrojejunostomy: nutritional status and clinical outcomePublication . Santos, Carla Adriana; Pereira, Marta; Martins, Vera Santos; Fonseca, Jorge"BACKGROUND: tracheoesophageal fistula (TEF) may result from cancer or mechanical ventilation. Endoscopic Gastrostomy or Gastrojejunostomy (PEG/PEG-J) is used for nutritional support. OBJECTIVE: in TEF-patients, evaluating nutritional status when PEG is performed, safety of PEG/PEG-J and clinical outcome. METHODS: from the files of PEG/PEG-J feed TEF-patients we collected: clinical data, Body Mass Index, albumin, transferrin and cholesterol when gastrostomy was performed, and clinical outcome globally and according with the TEF cause: Group 1: complication of mechanical ventilation, Group 2: cancer. RESULTS: twelve patients, 18-91 years (median: 53), 11 PEG, one PEG-J: six complications of ventilation (neurological diseases), 6 cancers. Mean period from TEF diagnosis until gastrostomy: 2 months in Group 1, 10 months in Group 2. In the day of the gastrostomy, patients presented with malnutrition parameters, most strikingly in the cancer group. Group 1: died a single patient, 3 closed the TEF, resuming oral intake, 2 are still PEG-feed. All cancer patients died (7 months after gastrostomy). One needed a jejunal extension to create a PEG-J. No more complications. CONCLUSION: PEG/PEG-J was safe in TEF-patients, but cancer patients underwent gastrostomy too late. In TEF-patients, PEG/PEG-J should be considered in a regular basis, earlier in the disease evolution, before established malnutrition."
- Intestinal Amyloidosis in common variable immunodeficiency and Rheumatoid ArthritisPublication . Meira, T.; Sousa, R.; Cordeiro, A.; Ilgenfritz, R.; Borralho, P.We present a case of reactive amyloidosis that developed secondary to common variable immunodeficiency and rheumatoid arthritis. A 66-year-old woman, with prior history of common variable immunodeficiency and rheumatoid arthritis, was referred to our clinic for chronic diarrhea investigation. The patient was submitted to colonoscopy with ileoscopy, which did not show relevant endoscopic alterations. However, undertaken biopsies revealed amyloid deposition. Since amyloidosis with GI involvement is a rare cause of chronic diarrhea, this pathology should be considered in etiologic investigation, especially when associated with chronic inflammatory diseases.
- Histórias da nossa terraPublication . Santos, Luis Carlos Rodrigues dos
- Refrigeration Cycle Efficiency Improvement Supported on Dual Response Optimization.Publication . Costa, Nuno; Garcia, João
- Bioethical perspectives for ageing: the documents produced by the Ethics CouncilsPublication . Nunes, LucíliaAging attracted keen interest in research, health, education as well as cross-sectors approaches. We researched what has been produced by the National Bioethics/Ethics Councils in the form of opinions or other documents, relating to aging and elderly people. In the websi-tes of the 28 EU councils and 12 other countries, we identified 4 documents relating to aging and 8 opinions, which we analyse. The Councils have proposed to draw the attention and reflection of public opinion to the elderly condition; all agree that the age has its own traits and that matters revert to a “culture of old age”, respect and promotion of a positive aging. Enhance the diversity of modes of aging and the importance of preparing all, promoting literacy for aging, creating social and legal protective elements (Elderly Statute, Observatory of the Elderly Conditions). From the analysis, a set of principles and bioethical elements: [1] respect for human dignity, regardless of the stage of life; [2] recognition of the person’s situation uniqueness to aging; [3] freedom of one’s own decision, which is materialized in respect for autonomy; [4] recognition of the vulnerabilities of the elderly, [5] ethical commitment and social responsibility in monitoring the elderly, [6] non-discrimination by age and [7] the guidance to the conditions of the integral good and quality of life. Aging is an existential step for which we can prepare, on the assumption that human life in its longevity, interweaves those who are older and those younger, on the crucial issue of human existence.